INT21179

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Context Info
Confidence 0.58
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 8.03
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
plasma 1
arm 1
striatum 1
foot 1
C cells 1
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 54 100.00 Very High Very High Very High
Enkephalin 1 99.92 Very High Very High Very High
dexamethasone 63 99.84 Very High Very High Very High
Dynorphin 59 99.80 Very High Very High Very High
rheumatoid arthritis 77 99.64 Very High Very High Very High
narcan 14 99.52 Very High Very High Very High
Clonidine 1 99.44 Very High Very High Very High
opiate 8 99.42 Very High Very High Very High
Opioid 18 99.10 Very High Very High Very High
antinociception 9 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 155 99.70 Very High Very High Very High
Rheumatoid Arthritis 77 99.64 Very High Very High Very High
Targeted Disruption 138 99.32 Very High Very High Very High
Adrenal Insufficiency 15 99.24 Very High Very High Very High
Stress 282 98.72 Very High Very High Very High
Nociception 4 97.96 Very High Very High Very High
Reprotox - General 1 8 97.72 Very High Very High Very High
Aggression 172 97.68 Very High Very High Very High
Neurodegenerative Disease 4 97.52 Very High Very High Very High
Increased Venous Pressure Under Development 12 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression.
Negative_regulation (Blockade) of CRF associated with stress, depression and neurodegenerative disease
1) Confidence 0.58 Published 2004 Journal Mol. Psychiatry Section Title Doc Link 14699428 Disease Relevance 0.96 Pain Relevance 0.33
The forskolin-stimulated CRH gene promoter activity is suppressed by dexamethasone in the BE(2)C cells which endogenously express CRH.
Negative_regulation (suppressed) of CRH gene in C cells associated with dexamethasone
2) Confidence 0.48 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.18
Moreover, sensorimotor performance on a rotorod was impaired, and water intake was reduced in corticotropin-releasing hormone overproducing mice, while no changes were seen in nociception.
Negative_regulation (reduced) of corticotropin-releasing hormone associated with nociception
3) Confidence 0.41 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099906 Disease Relevance 1.07 Pain Relevance 0.23
In further experiments, Schmidt and colleagues showed that in Npy deficient P8 mice deprived for 8hr, the decrease in hypothalamic CRH was attenuated, indicating that the Npy-mediated energy homeostasis pathway is crucial for the stress response in neonatal mice [18].
Negative_regulation (decrease) of CRH associated with stress
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.42 Pain Relevance 0.05
To investigate which vasodilatory molecules might be involved in the increase in vascular permeability, the CRH injection site was pretreated with the H1-receptor antagonist diphenhydramine, which largely inhibited the CRH effect, suggesting that histamine was involved in the CRH-induced vasodilation.
Negative_regulation (inhibited) of CRH associated with antagonist and increased venous pressure under development
5) Confidence 0.37 Published 1998 Journal Endocrinology Section Abstract Doc Link 9421440 Disease Relevance 0.45 Pain Relevance 0.30
In the systemic circulation, CRH and Ucn1 are known to bind CRH-binding protein (CRH-BP), resulting in the inactivation of CRH and Ucn1 (Potter et al. 1991).
Negative_regulation (inactivation) of CRH
6) Confidence 0.36 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.27
It is possible that GC reduces the CRH or vasopressin gene promoter activity, due to the inhibition of the activation of these transcription factors or signaling pathways at the transcriptional or posttranscriptional level.
Negative_regulation (reduces) of CRH
7) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.07
Three serial GRE half-sites are recognized in the above short sequences, all of which are involved in the negative regulation of the CRH gene transcription by the direct binding of GR. 8-bromo cAMP-induced CRH gene promoter activity is significantly reduced by glucocorticoid in AtT20 cells; however, this suppressive effect is abolished in the deleted or mutated construct lacking these nGRE site(s).
Negative_regulation (reduced) of CRH gene in AtT20
8) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.10
After lipopolysaccharide injection, the plasma corticosterone level is lower in either CRH or IL-6 knockout mice than in the wild-type; however, this stimulatory effect is almost unrecognized in CRH and IL-6 double knockout mice.
Negative_regulation (unrecognized) of CRH in plasma associated with targeted disruption
9) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.45 Pain Relevance 0.30
On the other hand, CRH heteronuclear (hn) RNA and mRNA expression are significantly decreased in adrenalectomized rats, after stress stimulation (Tanimura and Watts, 1998).
Negative_regulation (decreased) of CRH associated with stress
10) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.25 Pain Relevance 0
The cAMP-induced CRH promoter activity is reduced in the deletion construct which does not contain CRE.
Negative_regulation (reduced) of CRH promoter
11) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.19 Pain Relevance 0
Opiate-withdrawn CRF1-/- mice also showed aberrant CRF and dynorphin expression in the paraventricular nucleus of the hypothalamus (PVN) and the striatum, indicating profound impairments in stress-responsive brain circuitry.
Negative_regulation (showed) of CRF in striatum associated with stress, dynorphin and opiate
12) Confidence 0.34 Published 2007 Journal Neuron Section Abstract Doc Link 17296558 Disease Relevance 0.35 Pain Relevance 0.83
Naloxone at 1 and 10 mg/kg s.c. increased the ED50 value of CRF by 2- and 4-fold, respectively.
Negative_regulation (value) of CRF associated with narcan
13) Confidence 0.34 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2166788 Disease Relevance 0.13 Pain Relevance 1.27
The dose-response curve of CRF antinociception was shifted to the right by i.t. administered alpha-helical CRF (9-41), a CRF antagonist, and the ED50 was raised by 3.7-fold.
Negative_regulation (antagonist) of CRF associated with antinociception and antagonist
14) Confidence 0.34 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2166788 Disease Relevance 0.15 Pain Relevance 1.04
The dose-response curve of CRF antinociception was shifted to the right by i.t. administered alpha-helical CRF (9-41), a CRF antagonist, and the ED50 was raised by 3.7-fold.
Negative_regulation (antagonist) of CRF associated with antinociception and antagonist
15) Confidence 0.34 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2166788 Disease Relevance 0.15 Pain Relevance 1.04
Previous findings have indicated that CRF neurotransmission is decreased in association with lactation.
Negative_regulation (decreased) of CRF
16) Confidence 0.33 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.54 Pain Relevance 0
Surprisingly, the CRF-induced decrease in open arm time was blocked by pretreatment with the KOR-selective antagonist norbinaltorphimine (norBNI) (10 mg/kg, i.p.)
Negative_regulation (decrease) of CRF-induced in arm associated with antagonist and kappa opioid receptor
17) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.13 Pain Relevance 0.28
It has previously been speculated that decreased fear and anxiety (possibly via decreased CRF neurotransmission) during lactation may support maternal aggression by increasing the likelihood that a dam will attack a normally fear-evoking stimulus [4,29].
Negative_regulation (decreased) of CRF associated with aggression and anxiety disorder
18) Confidence 0.29 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.80 Pain Relevance 0
In association with lactation, the CNS becomes less sensitive to the anxiogenic neuropeptide, corticotropin-releasing factor (CRF) [2,3], suggesting that decreased CRF neurotransmission during lactation could support maternal care.
Negative_regulation (decreased) of CRF associated with neuropeptide
19) Confidence 0.29 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.18 Pain Relevance 0.05
Moreover, TRH blocked the rise in plasma glucose following central injection of corticotropin-releasing factor, enkephalin, clonidine and glucagon, as well as the hyperglycemic response to immobilization, electric foot shock or endotoxin administration.
Negative_regulation (injection) of corticotropin-releasing factor in foot associated with shock, enkephalin and clonidine
20) Confidence 0.29 Published 1988 Journal Peptides Section Abstract Doc Link 2896345 Disease Relevance 0.41 Pain Relevance 0.24

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