INT211806

Context Info Confidence 0.63 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 2.95 Pain Relevance 0.07

signal transduction (PLXNC1) cell adhesion (PLXNC1) plasma membrane (PLXNC1) intracellular (PLXNC1)

Anatomy Link Frequency thyroid 1 PLXNC1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 2 67.12 rheumatoid arthritis 3 26.56 Central nervous system 34 5.00 Inflammation 14 5.00 Spinal cord 12 5.00 cytokine 2 5.00 iatrogenic 2 5.00 fibrosis 2 5.00 Pain 2 5.00 headache 2 5.00

Disease Link Frequency Relevance Heat Measles 5 97.40 Rubella Virus Infection 18 97.04 Cytomegalovirus Infection 9 95.88 Hepatitis C Virus Infection 14 93.04 Arthritis 1 91.60 Diabetes Mellitus 5 90.48 Hepatitis B Virus Infection 4 90.40 Disease 115 89.80 Familial Combined Hyperlipidemia 254 89.76 Hepatitis 6 87.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The differential expression of nine genes (AGT, AK5, CNR1, GALR2, IGFBP7, KISSR1, PLXDC1, PLXNC1 and PROK2) was successfully validated using quantitative real-time PCR (Figure S2 and Table S9).

Gene_expression (expression) of PLXNC1

1) Confidence 0.63 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.28 Pain Relevance 0.07

We validated the differential expression of nine genes (AGT, AK5, CNR1, GALR2, IGFBP7, KISSR1, PLXDC1, PLXNC1 and PROK2) using quantitative real-time PCR (Figure S2).

Gene_expression (expression) of PLXNC1

2) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.34 Pain Relevance 0

In line with this observation, emerging evidence indicates that the length of this spacer is important for optimal viral protein synthesis as when short open reading frames are introduced between the IRES and the initiation codon viral protein synthesis in vitro and, in some instances, neurovirulence are diminished [7].

Gene_expression (synthesis) of viral protein

3) Confidence 0.01 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.07 Pain Relevance 0

In line with this observation, emerging evidence indicates that the length of this spacer is important for optimal viral protein synthesis as when short open reading frames are introduced between the IRES and the initiation codon viral protein synthesis in vitro and, in some instances, neurovirulence are diminished [7].

Gene_expression (synthesis) of viral protein

4) Confidence 0.01 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.08 Pain Relevance 0

Parvovirus viral protein 1 was detected in her bone marrow samples but no analysis was done on thyroid tissue [106].

Gene_expression (detected) of Parvovirus viral protein 1 in thyroid

5) Confidence 0.01 Published 2009 Journal Virol J Section Body Doc Link PMC2654877 Disease Relevance 2.19 Pain Relevance 0

General Comments

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