INT211807

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.09
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PTBP1) mRNA processing (PTBP1) nucleolus (PTBP1)
RNA binding (PTBP1) nucleus (PTBP1)
PTBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 43 97.20 Very High Very High Very High
Inflammation 31 88.60 High High
cytokine 56 70.52 Quite High
Inflammatory response 14 69.84 Quite High
antagonist 7 45.60 Quite Low
Central nervous system 34 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Dismenorea 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 230 100.00 Very High Very High Very High
Premature Birth 127 100.00 Very High Very High Very High
Rupture 16 99.54 Very High Very High Very High
Starvation 6 98.56 Very High Very High Very High
Nicotine Addiction 90 97.20 Very High Very High Very High
Hemorrhage 43 97.20 Very High Very High Very High
Disease 108 96.72 Very High Very High Very High
Neuroblastoma 4 93.04 High High
INFLAMMATION 45 88.60 High High
Syndrome 6 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of the interviewees and discussants associated the cause of PTB mainly with either exposure to cold air, starvation, dust, or frequent smoking/chewing Khat, which is similar to the beliefs found in a previous study in another part of Ethiopia [19].
PTB Binding (associated) of associated with mycobacterial infection, starvation and nicotine addiction
1) Confidence 0.31 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2867998 Disease Relevance 1.49 Pain Relevance 0
However, the participants associated the cause of PTB with exposure to cold air (45.9%), starvation (38%), dust (21.8%) or smoking/chewing Khat (Catha edulis) (16.4%).
PTB Binding (associated) of associated with mycobacterial infection, starvation and nicotine addiction
2) Confidence 0.31 Published 2010 Journal BMC Public Health Section Abstract Doc Link PMC2867998 Disease Relevance 1.27 Pain Relevance 0
Five genes from maternal data (CRHBP, FV, IL-5, tPA, and PTGER3) and three in fetal data (CBS, IL-10RA, and TREM1) that showed highly significant associations with PTB were analyzed for haplotype association.
PTB Binding (associations) of
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0 Pain Relevance 0
The nuclear protein polypyrimidine tract-binding protein (PTB), also known as hnRNP 1, which plays a role in alternative splicing of the cellular pre-mRNA [61,66,143], associates with three sites within the PV 5'NTR (nt 70–286, nt 443–539, and nt 630–730) as determined by UV-crosslinking [80].
PTB Binding (crosslinking) of
4) Confidence 0.21 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.47 Pain Relevance 0
Different polymorphisms may have an additive or synergistic effect on the risk for severity of the disease.63 Furthermore individual combinations of polymorphisms may up-or down-regulate each other.64 This may partially explain the reason that a certain polymorphism is associated with spontaneous PTB in one ethnic group, but not in a different ethnic group.
PTB Binding (associated) of associated with premature birth and disease
5) Confidence 0.21 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 0.88 Pain Relevance 0
In this pathway 3 of 6 genes examined had SNPs significantly associated with PTB.
PTB Binding (associated) of
6) Confidence 0.20 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2553267 Disease Relevance 0.43 Pain Relevance 0.11
In the present study a high-throughput candidate gene association analysis was performed on PTB candidate genes in an effort to further understand genetic factors associated with PTB in a US Caucasian sample.
PTB Binding (associated) of
7) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.14 Pain Relevance 0.11
Although the functional relevance of tPA variants are unknown, over expression of tPA leads to plasmin production, MMP activation and ECM degradation that is commonly associated with fetal membrane rupture and cervical ripening associated with PTB.
PTB Binding (associated) of associated with rupture
8) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.28 Pain Relevance 0.06
We replicated association with FV, a well established PTB candidate also found using a large-scale high throughput genotyping platform and identified new candidates [38].
PTB Binding (association) of
9) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.22 Pain Relevance 0.03
The nuclear protein polypyrimidine tract-binding protein (PTB), also known as hnRNP 1, which plays a role in alternative splicing of the cellular pre-mRNA [61,66,143], associates with three sites within the PV 5'NTR (nt 70–286, nt 443–539, and nt 630–730) as determined by UV-crosslinking [80].
tract-binding protein Binding (crosslinking) of
10) Confidence 0.18 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.47 Pain Relevance 0
PTB is associated with a 40-fold increase in neonatal morbidity and mortality [5]–[7].
PTB Binding (associated) of
11) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.18 Pain Relevance 0.04
Family history of PTB [9], [11]–[14], twin studies that estimated heritability between 20 and 40%, [15], [16], and association between ethnicity/race and PTB [11], [17] support this conclusion.
PTB Binding (association) of
12) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.27 Pain Relevance 0.10

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