INT211808

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.17
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB2) extracellular matrix organization (NFKB2) DNA binding (NFKB2)
cytoplasm (NFKB2) cytosol (NFKB2) signal transduction (NFKB2)
Anatomy Link Frequency
nucleus 2
muscle 1
HeLa 1
NFKB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 98.30 Very High Very High Very High
Inflammatory stimuli 1 98.26 Very High Very High Very High
Inflammatory response 15 92.28 High High
Inflammation 33 91.60 High High
cytokine 42 78.88 Quite High
antagonist 8 73.28 Quite High
Central nervous system 21 5.00 Very Low Very Low Very Low
tolerance 13 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 51 98.18 Very High Very High Very High
Apoptosis 15 94.96 High High
Syndrome 7 94.96 High High
Frailty 6 94.88 High High
Injury 20 93.64 High High
Systemic Lupus Erythematosus 1 93.52 High High
Appetite Loss 181 93.12 High High
Autoimmune Disease 1 92.60 High High
Death 17 92.20 High High
Lung Injury 3 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, injurious and inflammatory stimuli, such as free radicals present in the plasma of the immune deteriorated host leads to NFkB release that subsequently moves into the nucleus to activate the genes responsible for COX-2 expression.
Localization (release) of NFkB in nucleus associated with inflammatory stimuli
1) Confidence 0.19 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.60 Pain Relevance 0.29
Several recent laboratory studies have shown that EPA may attenuate protein degradation, by preventing NFkB accumulation in the nucleus [43, 44].
Localization (accumulation) of NFkB in nucleus
2) Confidence 0.14 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 0.93 Pain Relevance 0
Several recent laboratory studies have shown that n-3 fatty acid may attenuate protein degradation, potentially by preventing NFkB accumulation in the nucleus, preventing the degradation of muscle proteins.
Localization (accumulation) of NFkB in muscle
3) Confidence 0.14 Published 2010 Journal Curr Treat Options Oncol Section Abstract Doc Link PMC3016925 Disease Relevance 1.34 Pain Relevance 0.12
First characterized as HeLa cell protein p52, La is found in HeLa cell-free extracts but not in RLLs.
Neg (not) Localization (found) of p52 in HeLa
4) Confidence 0.11 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.42 Pain Relevance 0
It has been shown that steroids and nonsteroidal anti-inflammatory drugs are beneficial.22 Therefore, it is crucial to get a better insight in activation of NFkB and release of prostaglandins.
Localization (release) of NFkB associated with inflammation and cinod
5) Confidence 0.05 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.89 Pain Relevance 0.17

General Comments

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