INT211814

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.97
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chondrocytes 1
poly 1
polymerase (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 95.52 Very High Very High Very High
Osteoarthritis 64 95.16 Very High Very High Very High
rheumatoid arthritis 3 82.48 Quite High
Central nervous system 17 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 71 95.16 Very High Very High Very High
INFLAMMATION 15 95.16 Very High Very High Very High
Death 12 91.56 High High
Adhesions 2 90.72 High High
Rheumatoid Arthritis 3 82.48 Quite High
Stress 39 72.88 Quite High
Infection 17 54.08 Quite High
Apoptosis 23 35.68 Quite Low
Polio 56 5.00 Very Low Very Low Very Low
Sprains And Strains 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although prolonged application of fluid shear increased the mRNA synthesis of TCDD-inducible poly(ADP-ribose) polymerase (PARP-1) in human T/C-28a2 chondrocytes (Table 1), a recent microarray study reported this gene to be down-regulated in OA chondrocytes relative to normal controls [15].
Transcription (synthesis) of polymerase in chondrocytes associated with osteoarthritis
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.85 Pain Relevance 0.33
Human mitochondrial transcription requires bacteriophage-related RNA polymerase, POLRMT, mtDNA-binding protein, h-mtTFA/TFAM, and two transcription factors/rRNA methyltransferases, h-mtTFB1 and h-mtTFB2.
Transcription (transcription) of polymerase
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.07 Pain Relevance 0
Briefly, viral RNA replication starts with uridylylated VPg (VPg-pU-pU)-primed synthesis of complementary negative-strand RNA molecules via the transcription of poly(A) by the RNA dependent RNA polymerase 3Dpol.
Transcription (transcription) of polymerase 3Dpol in poly
3) Confidence 0.00 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.05 Pain Relevance 0

General Comments

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