INT211839

Context Info Confidence 0.36 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 0.79 Pain Relevance 0.18

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)

EIF4E (Homo sapiens)

Pain Link Frequency Relevance Heat cerebral cortex 40 66.76 ischemia 144 63.68 anesthesia 4 35.04 Central nervous system 34 5.00 Spinal cord 12 5.00 addiction 9 5.00 alcohol 4 5.00 iatrogenic 2 5.00 Inflammation 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Carcinoma 4 83.40 Renal Cell Carcinoma 29 82.24 Infection 35 78.52 Lung Cancer 1 66.16 Prostate Cancer 27 64.16 Cv Unclassified Under Development 140 63.68 Death 8 57.28 Stress 114 50.00 Metastasis 8 47.52 Cancer 56 41.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The everolimus-FKBP12 complex binds to mTOR and reduces the activity of the downstream effectors S6 ribosomal protein kinase (S6K1) and translational repressor protein eukaryotic elongation factor 4E-binding protein (4EBP).19 eIF-4F activation results in the translation of a subset of capped mRNA containing highly structured 5?

eIF-4F Binding (binding) of

1) Confidence 0.36 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.27 Pain Relevance 0

An important feature of the PV genomic RNA, a mRNA, that distinguishes it from most cellular mRNAs, is the absence of a 7-methyl guanosine (m7G) cap structure, which in cellular mRNAs interacts with the eIF4F cap-binding complex early in translation initiation of cellular proteins.

eIF4F Binding (interacts) of

2) Confidence 0.18 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.08 Pain Relevance 0

This interaction, which was not included in the model, was at least partially responsible for TOR activation and the eventual liberation of eIF4E.

eIF4E Binding (liberation) of

3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.13 Pain Relevance 0

An important feature of the PV genomic RNA, a mRNA, that distinguishes it from most cellular mRNAs, is the absence of a 7-methyl guanosine (m7G) cap structure, which in cellular mRNAs interacts with the eIF4F cap-binding complex early in translation initiation of cellular proteins.

eIF4F Binding (binding) of

4) Confidence 0.13 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.08 Pain Relevance 0

Active hypophosphorylated forms of 4E-BPs bind to eIF4E, compete with eIF4G, and inhibit eIF4G binding to eIF4E, which prevents eIF4F complex formation and inhibits cap-dependent translation (1–8).

eIF4F Binding (formation) of

5) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0

This allows eIF4E to bind eIF4G and formation of the eIF4F complex, which leads to translation activation (1–8).

eIF4F Binding (bind) of

6) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0

We studied the phosphorylation status of 4E-BP1 associated with eIF4E and the binding of eIF4G to eIF4E as eIF4F complex formation. eIF4E is identified by its ability to bind to the 5?

eIF4F Binding (binding) of

7) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.23 Pain Relevance 0.12

To study eIF4F complex formation and 4E-BP1 and eIF4G association with eIF4E, a cap-containing matrix was used as described previously (16, 19).

eIF4F Binding (formation) of

8) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0.06

General Comments

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