INT211878

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.01
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
PDL-1 1
CD86 1
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 27 51.68 Quite High
Inflammation 68 50.00 Quite Low
chemokine 14 45.60 Quite Low
Chronic pancreatitis 20 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 152 97.62 Very High Very High Very High
Adenocarcinoma 180 90.88 High High
Hypoxia 40 76.92 Quite High
Stress 1 72.00 Quite High
Carcinoma 5 62.80 Quite High
INFLAMMATION 68 50.00 Quite Low
Pancreatitis 20 5.00 Very Low Very Low Very Low
Metastasis 12 5.00 Very Low Very Low Very Low
Pancreatic Cancer 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purified MDCs and PDCs were matured with the TLR3 ligand Poly I:C and TLR9 ligand CpG, respectively, and assessed for CD40, CD83, CD86, PDL-1, ICOSL, B7H3, DCIR, CCR5, and CCR7 expression levels.
Transcription (levels) of CD40 in PDL-1
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.31 Pain Relevance 0
The purified MDCs and PDCs were matured with the TLR3 ligand Poly I:C and TLR9 ligand CpG, respectively, and assessed for CD40, CD83, CD86, PDL-1, ICOSL, B7H3, DCIR, CCR5, and CCR7 expression levels.
Transcription (levels) of CD40 in CD86
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.31 Pain Relevance 0
Tumor cells use the tumor suppressor p53, which is usually modified by mutations to debilitate cell cycle controls, to activate hexokinase gene transcription in particular the Type II isoform.
Transcription (transcription) of Type II isoform associated with cancer
3) Confidence 0.08 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1948005 Disease Relevance 1.38 Pain Relevance 0.03

General Comments

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