INT21188

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.62
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg)
Anatomy Link Frequency
dentate gyrus 1
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 20 99.96 Very High Very High Very High
Opioid 5 98.76 Very High Very High Very High
fluoxetine 8 97.20 Very High Very High Very High
opiate 4 96.56 Very High Very High Very High
Hippocampus 1 96.16 Very High Very High Very High
agonist 11 95.52 Very High Very High Very High
Enkephalin 3 95.32 Very High Very High Very High
Raphe 2 94.64 High High
opioid receptor 4 92.24 High High
Potency 13 89.08 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 12 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cys(Npys) blocked [35S]GTP gamma S binding as well as IAP-catalyzed ADP-ribosylation in purified Go.
Negative_regulation (blocked) of GTP gamma S
1) Confidence 0.37 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2166901 Disease Relevance 0.06 Pain Relevance 0.35
Boc-Cys(Npys), however, seems to stabilize the coupling state between the receptors and G proteins, thus abolishing the GTP gamma S effect.
Negative_regulation (abolishing) of GTP gamma S
2) Confidence 0.37 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2166901 Disease Relevance 0 Pain Relevance 0.14
Moreover, depending of the area analysed, the basal binding of [35S]GTPgammaS was differentially affected by this treatment: increased in DRN and decreased in hippocampal dentate gyrus.
Negative_regulation (decreased) of GTPgammaS in dentate gyrus
3) Confidence 0.26 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18809415 Disease Relevance 0 Pain Relevance 0.84
TRH was able to reverse inhibition of GTP gamma S-stimulated IP3 formation by GTP but could not reverse inhibition by GDP.
Negative_regulation (inhibition) of GTP gamma S
4) Confidence 0.21 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 3036863 Disease Relevance 0 Pain Relevance 0.07
While the effect of GTP(gammaS) was prevented by pretreatment with H7 (100 micro M), a non-selective PKA/PKC inhibitor, the fluoride-induced increase in Na(v)1.8 current was not sensitive to H7 (100 micro M), or to inclusion of deferoxamine (1 mM) in the intracellular solution.
Negative_regulation (effect) of gammaS
5) Confidence 0.06 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12898089 Disease Relevance 0 Pain Relevance 0.10
In contrast, the IC50 of GTP gamma S for inhibiting the enzyme is reduced by 55% in the presence of the opioid.
Negative_regulation (reduced) of GTP gamma S associated with opioid
6) Confidence 0.01 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3020173 Disease Relevance 0 Pain Relevance 0.43
GDP blocked the inhibitory effect of GTP gamma S (0.3 microM) in a concentration-dependent manner; the EC50 for GDP was 16 +/- 2.6 microM in the absence of morphine and 170 +/- 32 microM in the presence of morphine.
Negative_regulation (effect) of GTP gamma S associated with morphine
7) Confidence 0.01 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2540429 Disease Relevance 0.22 Pain Relevance 0.71
In membranes treated with pertussis toxin, there was an exaggerated lag in the onset of GTP gamma S inhibition of adenylyl cyclase activity; morphine could no longer affect this lag.
Negative_regulation (inhibition) of GTP gamma S associated with bordatella infection and morphine
8) Confidence 0.01 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2540429 Disease Relevance 0.34 Pain Relevance 0.62
The administration of 10 nM guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S) prevented morphine inhibition.
Negative_regulation (prevented) of GTP-gamma-S associated with morphine
9) Confidence 0.01 Published 1996 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8836576 Disease Relevance 0 Pain Relevance 0.89

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