INT211905

Context Info Confidence 0.07 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.25 Pain Relevance 0.48

chromosome segregation (RIOK3) kinase activity (RIOK3)

RIOK3 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 5 98.88 addiction 30 98.20 cannabis 5 80.76 Nicotine 1 79.76 cocaine 2 75.84 Opioid 1 74.64 drug abuse 5 58.48 opiate 9 50.00 tolerance 3 23.20 Buprenorphine 4 6.76

Disease Link Frequency Relevance Heat Drug Dependence 54 100.00 Attention Deficit Hyperactivity Disorder 155 97.94 Conduct Disorder 6 82.68 Cannabis Dependence 1 81.00 Nicotine Addiction 1 80.20 Adverse Drug Reaction 3 50.00 Opiate Addiction 1 50.00 Appetite Loss 4 45.64 Endometriosis (extended) 1 41.68 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 27.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Endothelial progenitor cells (EPC's) were lower in the SUD (0.09+0.14 Vs. 0.26+0.20 cells/mcl, Student's T = 2.25, df = 19, P = 0.0367) both by absolute counts, and when numbers with EPC counts less than 0.15 × 1011 were considered (Fisher Exact Test = 0.0299, Yates corrected Chi Squared 0.047, df = 1, O.R. = 0.09, C.I. 0.01–0.97) notwithstanding the significantly older age of the N-SUD group.

Negative_regulation (lower) of SUD associated with drug dependence

1) Confidence 0.07 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC1949819 Disease Relevance 0.24 Pain Relevance 0

Probands with ADHD who did not differ from those without ADHD in absolute rates of SUD, still had an earlier onset, a longer duration, and higher rates of severely impairing SUD as well as higher rates of alcohol and drug dependence than non-ADHD children [23].

Negative_regulation (impairing) of SUD associated with drug dependence, addiction, attention deficit hyperactivity disorder and alcohol

2) Confidence 0.01 Published 2010 Journal Eur Child Adolesc Psychiatry Section Body Doc Link PMC3012210 Disease Relevance 2.02 Pain Relevance 0.48

General Comments

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