INT211909

Context Info Confidence 0.21 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0.76

mitochondrion (Map2k1) Golgi apparatus (Map2k1) cytoplasm (Map2k1) cell proliferation (Map2k1) cytosol (Map2k1) mitosis (Map2k1)

Map2k1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 60 97.92 imagery 1 91.44 Nerve growth factor 1 90.28 Glutamate receptor 1 88.56 nMDA receptor 1 86.12 Spinal cord 35 71.68 Hippocampus 25 71.64 Lasting pain 17 65.04 Dorsal horn 8 61.32 medulla 3 18.68

Disease Link Frequency Relevance Heat Pain 82 97.92 Nociception 14 84.08 Hyperalgesia 9 5.00 Cognitive Disorder 5 5.00 INFLAMMATION 4 5.00 Nervous System Injury 2 5.00 Ganglion Cysts 2 5.00 Hypersensitivity 2 5.00 Hyperplasia 1 5.00 Depression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We suggest, to some extent, that it maybe due to the differential activation and regulation of upstream activators for ERK1 and ERK2 (MEK1 or MEK2, for example) in different areas under the pain states.

Regulation (regulation) of Positive_regulation (activators) of MEK1 associated with pain

1) Confidence 0.21 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.47 Pain Relevance 0.76

General Comments

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