INT211910

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.59
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) mitochondrion (Map2k2) Golgi apparatus (Map2k2)
nucleus (Map2k2)
Anatomy Link Frequency
spinal 1
Map2k2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 55 99.38 Very High Very High Very High
Spinal cord 35 92.52 High High
medulla 14 90.76 High High
Substantia nigra 1 87.36 High High
Hippocampus 25 86.64 High High
Nucleus accumbens 1 86.12 High High
Lasting pain 17 67.44 Quite High
Pain 60 50.00 Quite Low
Dorsal horn 8 37.28 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 4 90.52 High High
Death 62 85.44 High High
Pain 82 66.56 Quite High
Urological Neuroanatomy 1 8.60 Low Low
Nociception 14 5.00 Very Low Very Low Very Low
Hyperalgesia 9 5.00 Very Low Very Low Very Low
Poisoning 7 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, combined with our findings, we extrapolate from the previous results that it is probably due to the differential distribution of ERK kinase, MEK1 or MEK2 or other unknown additional members of this kinase family, that leads to the differential distribution of pERK1 and pERK2 between spinal and supraspinal level under normal state observed in the present study.
Negative_regulation (distribution) of MEK2 in spinal
1) Confidence 0.26 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.07 Pain Relevance 0.38
Similar results were obtained on local application bilaterally into RVLM of U0126 (5 pmol), a specific inhibitor of MEK1 and MEK2 [26,27] (fig. 1).
Negative_regulation (inhibitor) of MEK2 associated with rostral ventrolateral medulla
2) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.53 Pain Relevance 0.26

General Comments

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