INT211919

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.74
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epithelium 1
Dss1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 183 98.24 Very High Very High Very High
drug abuse 3 83.04 Quite High
Inflammation 109 80.84 Quite High
Lasting pain 42 74.20 Quite High
Cancer pain 9 66.80 Quite High
cytokine 36 58.24 Quite High
Pain management 18 17.04 Low Low
Pain 57 5.00 Very Low Very Low Very Low
Crohn's disease 14 5.00 Very Low Very Low Very Low
Analgesic 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 73 100.00 Very High Very High Very High
Hypertension 9 99.64 Very High Very High Very High
Mental Disorders 6 84.08 Quite High
Drug Dependence 6 83.04 Quite High
INFLAMMATION 104 80.84 Quite High
Cancer 12 75.52 Quite High
Pain 108 74.20 Quite High
Inflammatory Bowel Disease 47 69.56 Quite High
Recurrence 6 68.44 Quite High
Cancer Pain 18 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A valuable part of our process is collaboration of the DSS developers directly with the CPG authors.
Regulation (collaboration) of DSS
1) Confidence 0.32 Published 2010 Journal Implement Sci Section Body Doc Link PMC2868045 Disease Relevance 0.08 Pain Relevance 0.32
These comments helped clarify situations where clinicians might appropriately either ignore or decide against guideline recommended actions based on information not in the EMR, allowing alteration of the DSS to encourage less rigid use of recommendations in these circumstances.
Regulation (alteration) of DSS
2) Confidence 0.19 Published 2010 Journal Implement Sci Section Body Doc Link PMC2868045 Disease Relevance 0.52 Pain Relevance 0.39
We used an iterative development process involving authors of the CPG, local content experts, end-users (i.e., opioid prescribers), knowledge modelers, graphic designers, and systems software engineers to modify the initial ATHENA-DSS, ATHENA-Hypertension (HTN), to guide evidence-based opioid prescribing (Figure 1).
Regulation (modify) of DSS associated with hypertension and opioid
3) Confidence 0.19 Published 2010 Journal Implement Sci Section Body Doc Link PMC2868045 Disease Relevance 0.10 Pain Relevance 0.35
In order to study functional consequences of DSS-mediated colitis and EcN treatment and also the potential significance of ZO-1 up-regulation for an enhancement of intestinal barrier function, we performed experiments aimed to assess transport and barrier function of the colonic epithelium of DSS-treated mice with and without application of EcN.
Regulation (regulation) of DSS in epithelium associated with colitis
4) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.74 Pain Relevance 0.07
Lb. casei-treated groups are not significantly different from both DSS untreated and treated groups (data not shown).
Neg (not) Regulation (different) of DSS
5) Confidence 0.06 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.31 Pain Relevance 0.21
The effects of DSS treatment and Lb. casei administration were assessed by an ANOVA test using JUMP5.1® software.
Regulation (effects) of DSS
6) Confidence 0.06 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0 Pain Relevance 0

General Comments

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