INT211942

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.46
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx2) DNA binding (Runx2) transcription factor binding (Runx2)
cytoplasm (Runx2)
Anatomy Link Frequency
chondrocyte 2
osteoblast 1
hypertrophic chondrocytes 1
Runx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 182 81.92 Quite High
Kinase C 1 19.52 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 37 99.12 Very High Very High Very High
Targeted Disruption 6 89.44 High High
Hypertrophy 10 89.16 High High
Congenital Anomalies 4 86.96 High High
Cleidocranial Dysplasia 31 83.60 Quite High
Osteoarthritis 192 81.92 Quite High
Disease 26 81.48 Quite High
Aging 26 69.80 Quite High
Supernumerary Tooth 2 68.76 Quite High
Learning Disorders 2 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RUNX2 is a transcription factor essential for osteoblast differentiation and chondrocyte maturation during endochondral ossification [Zheng et al., 2005].
Transcription (transcription) of RUNX2 in osteoblast associated with osteoporosis
1) Confidence 0.69 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 1.10 Pain Relevance 0
RUNX2 is a transcription factor up-regulated during osteoblast differentiation, and is also expressed by some hypertrophic chondrocytes [35].
Transcription (transcription) of RUNX2 in hypertrophic chondrocytes associated with osteoporosis
2) Confidence 0.51 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.32 Pain Relevance 0
Signaling via Smad1 cooperates with the transcription factor Runx2 (CBFA1) to induce chondrocyte terminal differentiation.
Transcription (transcription) of Runx2 in chondrocyte
3) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.52 Pain Relevance 0.04
Signaling via Smad1 cooperates with the transcription factor Runx2 (CBFA1) to induce chondrocyte terminal differentiation.
Transcription (transcription) of CBFA1 in chondrocyte
4) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.52 Pain Relevance 0.04

General Comments

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