INT21196

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Context Info
Confidence 0.11
First Reported 1990
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grik4) nucleus (Grik4)
Anatomy Link Frequency
spinal 1
neurons 1
Grik4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 8 98.80 Very High Very High Very High
algogenic 2 94.64 High High
addiction 1 94.60 High High
intrathecal 5 88.64 High High
Spinal cord 4 83.16 Quite High
Kinase C 2 75.00 Quite High
antagonist 5 60.16 Quite High
agonist 1 47.16 Quite Low
nociceptor 3 25.00 Low Low
Pain 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results provide strong in vivo evidence to support the idea that nNOS but not COX-2, plays an important role in spinal KA receptor activation.
Positive_regulation (activation) of KA receptor in spinal
1) Confidence 0.11 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489538 Disease Relevance 0 Pain Relevance 0.48
The results of this study demonstrate a distinct pharmacological profile for the KA receptor system coupled to the evoked release of [3H]GABA from striatal neurons.
Positive_regulation (coupled) of KA receptor in neurons associated with gaba
2) Confidence 0.09 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2166903 Disease Relevance 0 Pain Relevance 0.23

General Comments

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