INT211968

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 9.33
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Best1) plasma membrane (Best1)
Anatomy Link Frequency
spinal 2
neck 1
liver 1
Best1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 93.04 High High
ischemia 2 87.96 High High
Spinal cord 34 81.68 Quite High
Bile 3 74.44 Quite High
cytokine 33 54.72 Quite High
corticosteroid 1 50.48 Quite High
fibrosis 24 49.40 Quite Low
Somatostatin 18 49.00 Quite Low
Sciatic nerve 78 40.32 Quite Low
tolerance 3 39.84 Quite Low
Disease Link Frequency Relevance Heat
Celiac Disease 18 99.44 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

33 99.38 Very High Very High Very High
Sickle Cell Anemia 6 99.28 Very High Very High Very High
Liver Failure 3 98.88 Very High Very High Very High
Thalassemia 6 98.20 Very High Very High Very High
Reprotox - General 1 31 97.88 Very High Very High Very High
Reprotox - General 2 6 96.92 Very High Very High Very High
Growth Problems 15 96.48 Very High Very High Very High
Targeted Disruption 56 95.56 Very High Very High Very High
Disease 156 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VMD2 is located on chromosome 11q13, and encodes the 585 aa protein Bestrophin.
Localization (located) of VMD2
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.65 Pain Relevance 0.17
As stated above, VMD2 was originally identified as being localized to RPE cells.
Localization (localized) of VMD2
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.09 Pain Relevance 0.04
However, both VCD-treated and OVX animals experienced a decline (P < .05) from baseline in BMD starting on d59 (age: ~11–14 months; ~1 month after ovarian failure or surgery in VCD and OVX mice) and continuing to the end of the study (VCD: 0.051 ± 0.001 to 0.043 ± 0.004?
Localization (baseline) of BMD associated with reprotox - general 1
3) Confidence 0.10 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951122 Disease Relevance 0.32 Pain Relevance 0
Their data indicate that while spinal BMD (mg/cm2) in VCD-treated mice took 2.9 months after the event of ovarian follicle depletion to decrease relative to controls, age-matched OVX mice exhibited a decreased spinal BMD versus controls as soon as 1 months after ovariectomy.
Localization (decreased) of BMD in spinal
4) Confidence 0.08 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951124 Disease Relevance 0.15 Pain Relevance 0
Their data indicate that while spinal BMD (mg/cm2) in VCD-treated mice took 2.9 months after the event of ovarian follicle depletion to decrease relative to controls, age-matched OVX mice exhibited a decreased spinal BMD versus controls as soon as 1 months after ovariectomy.
Localization (decrease) of BMD in spinal
5) Confidence 0.08 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951124 Disease Relevance 0.17 Pain Relevance 0
When BMD was set constant at a T-score of ?
Localization (set) of BMD
6) Confidence 0.06 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2267485 Disease Relevance 1.08 Pain Relevance 0
When the BMD was set at an average for women (Z-score?
Localization (set) of BMD
7) Confidence 0.06 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2267485 Disease Relevance 0.55 Pain Relevance 0
Brinker et al. [80] found low BMD in children with sickle cell anemia.
Localization (found) of BMD associated with sickle cell anemia
8) Confidence 0.03 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.47 Pain Relevance 0.03
D’Antiga et al. [15] found normal LS BMC and BMD in patients with childhood liver failure who were at least 1 year out from orthotopic liver transplantation.
Localization (found) of BMD in liver associated with liver failure
9) Confidence 0.03 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.07 Pain Relevance 0.04
Kalayci et al. [9] found lower LS BMD in untreated celiac disease patients compared to treated patients.
Localization (found) of BMD associated with celiac disease
10) Confidence 0.03 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.93 Pain Relevance 0.07
Thereafter, remarkable improvement of BMD can be observed in almost all patients after a normalization period of cortisol levels lasting 12–36 months.92 Similarly, in a retrospective study of 17 patients with Cushing syndrome, after several years of cure, normalization of BMD at lumbar spine and femoral neck was reported.93
Localization (normalization) of BMD in neck
11) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.62 Pain Relevance 0.03

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