INT211970

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 49
Total Number 50
Disease Relevance 37.33
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Best1) plasma membrane (Best1)
Anatomy Link Frequency
hip 3
forearm 2
follicle 2
radial 1
cranial 1
Best1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 296 99.84 Very High Very High Very High
withdrawal 3 98.40 Very High Very High Very High
methotrexate 222 93.24 High High
Inflammation 186 87.44 High High
Arthritis 37 77.64 Quite High
cytokine 37 68.56 Quite High
rheumatoid arthritis 47 60.16 Quite High
Pain 12 57.12 Quite High
Central nervous system 37 52.24 Quite High
Lasting pain 38 46.80 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 99.92 Very High Very High Very High
Meningomyelocele 185 99.88 Very High Very High Very High
Muscular Dystrophy 185 99.88 Very High Very High Very High
Osteogenesis Imperfecta 299 99.84 Very High Very High Very High
Cystic Fibrosis 296 99.84 Very High Very High Very High
Asthma 185 99.84 Very High Very High Very High
Eating Disorder 149 99.84 Very High Very High Very High
Bone Cancer 77 99.84 Very High Very High Very High
Osteoporosis 347 99.82 Very High Very High Very High
Hyperthyroidism 37 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
currents in retinal pigment epithelial cells are not abolished in mouse bestrophin-1 (mBest1) knockout mice (Marmorstein et al., 2006).
Neg (not) Negative_regulation (abolished) of mBest1 in epithelial cells associated with targeted disruption
1) Confidence 0.14 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.25 Pain Relevance 0
After treatment withdrawal, patients who switched to a placebo after four years experienced a significant reduction in BMD, showing how SR effects had been progressively reversible and reflecting the clearance of strontium from the bone.24

Bone turnover markers

Negative_regulation (reduction) of BMD associated with withdrawal
2) Confidence 0.09 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.09 Pain Relevance 0.05
In that study, young OVX mice showed reduced lumbar BMD when compared to cycling animals 1 month after ovariectomy while BMD from VCD-treated, follicle-depleted animals did not differ until approximately 3 months after VCD-induced ovarian failure.
Negative_regulation (reduced) of BMD in follicle associated with reprotox - general 1
3) Confidence 0.06 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951122 Disease Relevance 0.35 Pain Relevance 0
Accelerated loss of bone mineral density (BMD) has been associated with the loss of estrogen following menopause [6, 7].
Negative_regulation (loss) of BMD associated with endometriosis (extended)
4) Confidence 0.06 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951122 Disease Relevance 1.13 Pain Relevance 0
The opposite finding was suggested by Braga et al. [34] who reported that the CC genotype is associated with decreased BMD and is more common in men with hip or vertebral fractures than in control subjects [34].
Negative_regulation (decreased) of BMD in hip
5) Confidence 0.06 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.47 Pain Relevance 0
By 3.4-months postovarian follicle depletion or OVX, the decline in spinal BMD was similar for VCD-treated and OVX mice and both models exhibited BMDs that were comparably lower than control mice.
Negative_regulation (decline) of BMD in follicle
6) Confidence 0.05 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951124 Disease Relevance 0.14 Pain Relevance 0
Their data indicate that while spinal BMD (mg/cm2) in VCD-treated mice took 2.9 months after the event of ovarian follicle depletion to decrease relative to controls, age-matched OVX mice exhibited a decreased spinal BMD versus controls as soon as 1 months after ovariectomy.
Negative_regulation (decreased) of BMD in spinal
7) Confidence 0.05 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951124 Disease Relevance 0.15 Pain Relevance 0
The efficacy of zoledronic acid for prevention of AIBL in postmenopausal women was evaluated by three large parallel designed trials20,21 (Z-FAST, ZO-FAST, and E-ZO-FAST) which randomized patients – who received letrozole 2.5 mg/day for up to 5 years – to zoledronic acid 4 mg every 6 months either at initiation of letrozole treatment (immediate group) or at the time of BMD decline (T-score ?
Negative_regulation (decline) of BMD in AIBL
8) Confidence 0.04 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2690973 Disease Relevance 0.12 Pain Relevance 0
The function of LRP5 in bone development, however, is indisputable [41]; mutations in LRP5 cause various bone disorders [20,42] and polymorphisms are associated with BMD and bone mineral content in general [43], but also with reduced BMD and fractures [44].
Negative_regulation (reduced) of BMD associated with bone cancer
9) Confidence 0.04 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.85 Pain Relevance 0
Many well-controlled prospective studies with dual energy X-ray absorptiometry (DXA), particularly in elderly women, indicate that the risk of fracture about doubles for each SD reduction in BMD [2, 3].
Negative_regulation (reduction) of BMD
10) Confidence 0.03 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2267485 Disease Relevance 0.97 Pain Relevance 0
Mul et al. [116] found marked reductions in LS BMD and BMC in children with rheumatic diseases treated for at least 1 year with high-dose CS.
Negative_regulation (reductions) of BMD associated with rheumatic diseases
11) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.06 Pain Relevance 0.11
Allen et al. [78] and Harris et al. [79] found significant reductions in BMD in asthmatic children receiving high doses of inhaled CS.


Negative_regulation (reductions) of BMD associated with asthma
12) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.39 Pain Relevance 0.08
Gonadal dysfunction due to pelvic or cranial irradiation was the factor most strongly correlated with reduced BMD.
Negative_regulation (reduced) of BMD in cranial associated with gonadal disease
13) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.64 Pain Relevance 0.08
Interestingly, they found that those diagnosed prior to puberty had more severe BMD reductions later in life.
Negative_regulation (reductions) of BMD
14) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.74 Pain Relevance 0.04
Vogiatzi et al. [85] and Benigno et al. [86] evaluated children with thalassemia major who were fully treated with transfusion and chelation therapy and found reduced BMD at diagnosis and showed further reductions at follow-up.
Negative_regulation (reduced) of BMD associated with thalassemia
15) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.33 Pain Relevance 0
Several authors found that the height-corrected LS BMD was reduced for up to 2 years after transplantation; this was felt to be due to high-dose CS treatment required to suppress transplant rejection.
Negative_regulation (reduced) of BMD associated with graft vs host disease
16) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.71 Pain Relevance 0
Because of the multifactorial nature of reduced BMD in CF, BMD Z-scores often reflect the severity of illness.
Negative_regulation (reduced) of BMD associated with fibrosis
17) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.21 Pain Relevance 0.31
In summary, patients with Duchenne muscular dystrophy have reduced LS BMD, especially in the setting of CS treatment.
Negative_regulation (reduced) of BMD associated with muscular dystrophy
18) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.86 Pain Relevance 0
Arikoski et al. [89] found reduced BMD in ALL survivors up to 20 years after treatment.
Negative_regulation (reduced) of BMD
19) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.77 Pain Relevance 0.04
Five of six extremities involved with a bone sarcoma showed reduced BMD.
Negative_regulation (reduced) of BMD associated with bone cancer
20) Confidence 0.02 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.71 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox