INT211971

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 7.73
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Best1) plasma membrane (Best1)
Anatomy Link Frequency
neck 1
hip 1
Best1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 21 92.48 High High
antagonist 14 86.76 High High
spinal inflammation 13 56.24 Quite High
Spinal cord 2 53.04 Quite High
imagery 23 46.88 Quite Low
Inflammation 18 42.00 Quite Low
backache 1 33.88 Quite Low
agonist 4 22.16 Low Low
Pain 14 21.40 Low Low
alcohol 19 15.60 Low Low
Disease Link Frequency Relevance Heat
Osteoporosis 579 100.00 Very High Very High Very High
Disease 157 99.18 Very High Very High Very High
Osteogenesis Imperfecta 17 97.20 Very High Very High Very High
Muscular Dystrophy 5 96.64 Very High Very High Very High
Osteoporotic Fractures 91 96.52 Very High Very High Very High
Syndrome 46 95.44 Very High Very High Very High
Bone Fracture 72 93.60 High High
Dermatomyositis 2 93.20 High High
Rheumatoid Arthritis 21 92.48 High High
Obesity 87 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, a gene previously associated with low BMD.
BMD Binding (associated) of
1) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.18 Pain Relevance 0.04
When tested in the overall BMD cohort, these regions did achieve moderate level association with BMD (2p16, P = 8 × 10-7; LRP4, P = 3 × 10-4).
BMD Binding (association) of
2) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.14 Pain Relevance 0
Monogenic skeletal diseases affecting BMD are summarized in Table 1; genetic associations with general community BMD are summarized elsewhere [33].
BMD Binding (associations) of associated with disease
3) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.61 Pain Relevance 0
How such genetic tests interact with traditional osteoporosis risk factors (such as BMD) has yet to be established.
BMD Binding (interact) of associated with osteoporosis
4) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.10 Pain Relevance 0
Five regions were identified that achieved genome-wide significance for association with BMD.
BMD Binding (association) of
5) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.20 Pain Relevance 0.04
It is likely that in a high proportion of individuals with extreme phenotypes (such as extreme high or low BMD in humans) a monogenic – usually rare – mutation underlies their extreme phenotype, as has been demonstrated, for example, with osteogenesis imperfecta type 1 and Marfan's syndrome.
BMD Spec (likely) Binding (underlies) of associated with syndrome and osteogenesis imperfecta
6) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.55 Pain Relevance 0
No gene achieved genome-wide significance for fracture, but moderate levels of association (P = 10-3 to 10-4) were seen for the 1p36 region, the major histocompatibility complex, RANK, and two regions not initially detected through association with BMD, namely 2p16 and 11p11 (the latter containing the gene LRP4).
BMD Neg (not) Binding (association) of
7) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.15 Pain Relevance 0
The importance of these studies is not just in confirming the significance of LRP5, which was already established: rather, they serve as proof-of-concept that whole-genome-wide association approaches successfully identify quantitative trait loci that underlie BMD and osteoporosis.
BMD Binding (underlie) of associated with osteoporosis
8) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.56 Pain Relevance 0
ESR1 variants associated with BMD were not associated with fracture; this is in disagreement with a prospective meta-analysis of 18,917 individuals performed by the GENOMOS consortium [53], which identified association with fracture but not BMD.
BMD Binding (association) of
9) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.05 Pain Relevance 0
Overall, the fracture studies suggest that fracture has a lower heritability than BMD, particularly among the elderly.
BMD Binding (heritability) of
10) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.60 Pain Relevance 0
Thus, no gene was identified to have significant association with fracture but not with BMD.
BMD Neg (not) Binding (association) of
11) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.13 Pain Relevance 0
Several studies report an association between the CTR polymorphism AluI and lumbar spine and femoral neck BMD in both men and women, but the reports have been somewhat contradictory.
BMD Binding (association) of in neck
12) Confidence 0.04 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.56 Pain Relevance 0
The measurement of a risk factor for diagnostic use, however, can only capture one aspect of the likelihood of the outcome when the disease is multifactorial, and in osteoporosis, assessment with BMD captures a minority of the fracture risk.
BMD Binding (assessment) of associated with osteoporosis and disease
13) Confidence 0.03 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2267485 Disease Relevance 0.96 Pain Relevance 0
In the presence of BMD, however, no additional risk is assumed in the presence of secondary osteoporosis, since its independence of BMD is uncertain.
BMD Binding (independence) of associated with osteoporosis
14) Confidence 0.03 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2267485 Disease Relevance 1.19 Pain Relevance 0.25
Due to the investigational nature of the study to evaluate the association of local BMD with the occurrence of specific types of treatment complications, the entire reporting process of complications/adverse events (AE) is adapted such that the investigators are obligated to report all types of events, independent of being classified as a complication or an AE.
BMD Binding (association) of
15) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2992478 Disease Relevance 0 Pain Relevance 0
Bone size as well as bone quality are other important components that interact with BMD in determining the risk of fracture.


BMD Binding (interact) of
16) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643104 Disease Relevance 0.96 Pain Relevance 0
The low LS and hip BMD worsen with loss of ambulatory status and are frequently associated with fractures of the lower extremities.
BMD Binding (associated) of in hip
17) Confidence 0.01 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.79 Pain Relevance 0

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