INT211972

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 12.04
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Best1) plasma membrane (Best1)
Anatomy Link Frequency
vertebrae 2
cranial 1
pore 1
femurs 1
Best1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 42 97.28 Very High Very High Very High
Inflammation 58 94.40 High High
Central nervous system 12 91.12 High High
ischemia 4 90.80 High High
spinal inflammation 3 87.36 High High
cytokine 22 57.56 Quite High
Bile 7 45.64 Quite Low
anesthesia 11 28.24 Quite Low
cva 16 20.72 Low Low
Pain 27 17.08 Low Low
Disease Link Frequency Relevance Heat
Disease 221 99.98 Very High Very High Very High
Growth Problems 35 99.72 Very High Very High Very High
Brain Tumor 14 99.68 Very High Very High Very High
Targeted Disruption 42 99.20 Very High Very High Very High
Appetite Loss 21 98.92 Very High Very High Very High
Osteoporosis 339 98.80 Very High Very High Very High
Acid Base Imbalance 7 98.36 Very High Very High Very High
Menopausal Vasomotor Symptoms 12 97.84 Very High Very High Very High
Anaemia 21 97.56 Very High Very High Very High
Age-related Macular Degeneration 10 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We constructed transgenic mice expressing murine IL-10 under the control of the human VMD2 gene promoter in B6CBAF2/J founder mice [3].
Regulation (control) of VMD2 associated with targeted disruption
1) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.66 Pain Relevance 0.18
Thus, although it is clearly important to determine whether BMD-associated polymorphisms influence bone fragility (the ultimate question), the most powerful approach is likely to be initial screens targeting genes that affect BMD, with subsequent testing to determine the relevance of such genes to fracture.
Regulation (affect) of BMD
2) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.50 Pain Relevance 0
Monogenic skeletal diseases affecting BMD are summarized in Table 1; genetic associations with general community BMD are summarized elsewhere [33].
Regulation (affecting) of BMD associated with disease
3) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.60 Pain Relevance 0
Already, these studies have identified novel pathways that contribute to control of BMD and bone fragility with possible therapeutic targets.
Spec (possible) Regulation (control) of BMD
4) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.73 Pain Relevance 0.13
Here, we provide compelling evidence to support the idea that bestrophin-1 is the pore-forming subunit of a cell volume-regulated anion channel (VRAC) in Drosophila S2 cells.
Regulation (regulated) of bestrophin-1 in pore
5) Confidence 0.09 Published 2008 Journal The Journal of General Physiology Section Abstract Doc Link PMC2571971 Disease Relevance 0.09 Pain Relevance 0
Human observational studies suggest that isoflavone effects on BMD are evident in women consuming >40–60?
Regulation (effects) of BMD
6) Confidence 0.05 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951124 Disease Relevance 0.14 Pain Relevance 0
Hypothetical mechanisms of action, the effects on bone mineral density (BMD), bone turnover markers, antifracturative efficacy and safety of SR are discussed in this work.


Regulation (effects) of BMD
7) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.62 Pain Relevance 0
Comparable BMD responses were observed with bazedoxifene and raloxifene at the femoral sites.
Regulation (responses) of BMD
8) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643104 Disease Relevance 0.11 Pain Relevance 0
Thus, different components of bone strength (ie, bone material properties and/or microarchitecture), not captured by changes in BMD, may contribute to the reduction in fracture risk observed with SERMs such as raloxifene and bazedoxifene.
Regulation (changes) of BMD
9) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643104 Disease Relevance 0.06 Pain Relevance 0
Preliminary data from phase 3 clinical trials appear to confirm this hypothesis, showing a greater effect of bazedoxifene on BMD with respect to raloxifene, coupled with efficacy on menopausal vasomotor symptoms not achieved by SERM alone.
Regulation (effect) of BMD associated with menopausal vasomotor symptoms
10) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2643104 Disease Relevance 0.34 Pain Relevance 0
The authors postulated that the higher cranial radiation doses used for the treatment of brain tumors had a profound effect on long-term BMD compared to the relatively lower doses used in the treatment of ALL.
Regulation (effect) of BMD in cranial associated with brain tumor
11) Confidence 0.01 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.18 Pain Relevance 0.07
The BMD values were normal for the group.
Regulation (values) of BMD
12) Confidence 0.01 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0 Pain Relevance 0.12
Additional factors that affect the BMD in these patients include malnutrition, metabolic acidosis, anemia and growth hormone abnormalities resulting in growth retardation.
Regulation (affect) of BMD associated with appetite loss, anaemia, congenital anomalies and acid base imbalance
13) Confidence 0.01 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.34 Pain Relevance 0
In summary, there are multiple factors that affect short- and long-term BMD in these patients/survivors.
Regulation (affect) of BMD
14) Confidence 0.01 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.38 Pain Relevance 0.07
There are only limited data regarding the effects of other childhood malignancies on BMD.
Regulation (effects) of BMD
15) Confidence 0.01 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.49 Pain Relevance 0.10
The effects of hormonal birth control use on BMD in adolescent girls have been investigated by several researchers.
Spec (investigated) Regulation (effects) of BMD
16) Confidence 0.01 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.43 Pain Relevance 0
As with many chronic medical conditions, short stature will greatly affect BMD and needs to be accounted for in DXA interpretation.
Regulation (affect) of BMD associated with growth problems
17) Confidence 0.01 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 1.22 Pain Relevance 0
We observed no significant difference in the BMD values of the femurs among the three operated groups, whereas at the distal region the BMD values in the three operated groups were significantly lower than that in the nonoperated CTL group (Figure 5).
Regulation (values) of BMD in femurs
18) Confidence 0.00 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952315 Disease Relevance 0.44 Pain Relevance 0
Only the BMD values of the lumbar vertebrae proximal to the SMF-exposed area were significantly higher in the SMF group than those in the sham group, which is approximately the same level as the nonoperated CTL group (Figure 6).
Regulation (values) of BMD in vertebrae
19) Confidence 0.00 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952315 Disease Relevance 0.31 Pain Relevance 0
The BMD values of the second and the third lumbar vertebrae (L2, L3), and the total average BMD values from the second to the fourth lumbar vertebrae (L2-4) of the OVX group were significantly lower than those of the CTL group (L2, P < .001; L3, P < .01; L4, P < .05; L2-4, P < .01, Figure 6).
Regulation (values) of BMD in vertebrae
20) Confidence 0.00 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952315 Disease Relevance 0.33 Pain Relevance 0

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