INT211996

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Erbb3, Nrg1) cell proliferation (Nrg1) signal transduction (Erbb3)
cell morphogenesis (Nrg1) plasma membrane (Nrg1) nucleus (Erbb3)
Erbb3 (Mus musculus)
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3 93.00 High High
Peripheral nerve injury 2 19.52 Low Low
Peripheral nervous system 6 13.12 Low Low
Inflammation 46 5.00 Very Low Very Low Very Low
Spinal cord 32 5.00 Very Low Very Low Very Low
Central nervous system 17 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 56 98.00 Very High Very High Very High
Targeted Disruption 3 78.56 Quite High
Malformations Of Cortical Development 7 60.64 Quite High
Wallerian Degeneration 1 58.84 Quite High
Injury 21 55.16 Quite High
Nervous System Injury 4 40.08 Quite Low
Frailty 20 36.24 Quite Low
INFLAMMATION 61 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further investigated the effects induced by reelin and found that signaling was mediated via VLDLR/Dab1/Pi3K activation while NRG1 signaling was mediated via erbB3/erbB4/Pi3K.
erbB3 Positive_regulation (mediated) of NRG1
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0
ErbB3, a neuregulin receptor that is necessary for normal myelination.
ErbB3 Positive_regulation (necessary) of neuregulin receptor
2) Confidence 0.00 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.61 Pain Relevance 0.11

General Comments

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