INT2120

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2011
Negated 16
Speculated 3
Reported most in Abstract
Documents 159
Total Number 162
Disease Relevance 111.69
Pain Relevance 17.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD79A)
Anatomy Link Frequency
blood 5
B-cells 5
plasma cells 4
capsule 3
urine 3
CD79A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 558 100.00 Very High Very High Very High
intrathecal 67 99.98 Very High Very High Very High
rheumatoid arthritis 334 99.48 Very High Very High Very High
Inflammation 861 99.26 Very High Very High Very High
spinal inflammation 33 99.00 Very High Very High Very High
Opioid 1 98.84 Very High Very High Very High
Angina 3 97.92 Very High Very High Very High
imagery 38 97.88 Very High Very High Very High
backache 4 97.82 Very High Very High Very High
peptic ulcer disease 11 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epstein-barr Virus 406 100.00 Very High Very High Very High
Renal Disease 46 100.00 Very High Very High Very High
Skin Diseases 8 100.00 Very High Very High Very High
Hypercalcemia 7 100.00 Very High Very High Very High
Mycobacterial Infection 6 100.00 Very High Very High Very High
Pancytopenia 4 100.00 Very High Very High Very High
Diffuse Large B-cell Lymphoma 13 99.98 Very High Very High Very High
Chronic Renal Failure 9 99.92 Very High Very High Very High
Malabsorption Syndromes 83 99.90 Very High Very High Very High
Relapsing Polychondritis 4 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By immunohistochemistry the lymphoplasmacellular infiltrate showed polyclonal expression of IgA without IgA increase in serum, urine and duodenal juice.
Gene_expression (expression) of IgA in urine
1) Confidence 0.78 Published 1991 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 1874129 Disease Relevance 0.59 Pain Relevance 0.12
The gut has a highly specialized immune apparatus, particularly involving the production of protective secretory immunoglobulin A (IgA), but also involving T-cell immunity.
Gene_expression (production) of IgA in gut
2) Confidence 0.76 Published 1992 Journal Agents Actions Section Abstract Doc Link 1442333 Disease Relevance 0.13 Pain Relevance 0.04
IgG/IgM/IgA aCL and anti-beta2-gpI were detected by enzyme-linked immunoabsorbant assays (ELISA).
Gene_expression (detected) of IgA
3) Confidence 0.75 Published 2007 Journal Angiology Section Abstract Doc Link 17626983 Disease Relevance 1.39 Pain Relevance 0.17
These findings suggest that serum IgA antibodies against type I, III and IV collagens were mainly produced in secretory lesions in AS patients.
Gene_expression (produced) of IgA associated with spinal inflammation
4) Confidence 0.75 Published 1997 Journal Scand. J. Rheumatol. Section Abstract Doc Link 9385351 Disease Relevance 0.44 Pain Relevance 0.44
The lymphocytes express B-cell markers (CD19, CD20, and CD79a) and are negative for CD3, CD5, CD10, CD23, and cyclin D1.
Gene_expression (express) of CD79a in lymphocytes
5) Confidence 0.75 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 1.53 Pain Relevance 0.26
RESULTS: A predominant absence of intrathecal immunoglobulin synthesis and two patients with IgA and IgM synthesis was produced. 66% of cerebrospinal blood barrier dysfunction, 6.26 10 3 mean albumin ratio, lactate below 2.1 mmol/L and glucose concentration in cerebrospinal fluid was 50% over glucose blood content and 168 cells 10 6 L mainly lymphocytes were observed.
Gene_expression (synthesis) of IgA in blood
6) Confidence 0.75 Published 2002 Journal Rev Neurol Section Body Doc Link 12389166 Disease Relevance 0.33 Pain Relevance 0
Pathology revealed small to medium-sized cells with a moderate amount of cytoplasm and irregular nuclear borders, expressing pan B-cell markers (CD19, CD20, and CD79a) but lacking CD10, CD23, and cyclin D1, confirming low-grade MALT lymphoma.
Gene_expression (expressing) of CD79a in MALT associated with lymphatic system cancer
7) Confidence 0.75 Published 2009 Journal Clinical lymphoma & myeloma Section Abstract Doc Link 19525185 Disease Relevance 0.94 Pain Relevance 0.36
[A case of relapsing polychondritis with IgA nephropathy].
Gene_expression (nephropathy) of IgA associated with relapsing polychondritis and renal disease
8) Confidence 0.68 Published 1998 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Title Doc Link 9884550 Disease Relevance 1.10 Pain Relevance 0.08
Immunohistochemically, the cancer cells were positive for cytokeratin, epithelial membrane antigen, but not for vimentin, S-100, or hematopoietic markers of plasma cells such as CD79alpha and CD38.
Neg (not) Gene_expression (positive) of CD79alpha in plasma cells associated with cancer
9) Confidence 0.65 Published 2009 Journal Diagn. Cytopathol. Section Abstract Doc Link 19217039 Disease Relevance 0.81 Pain Relevance 0.07
Routine laboratory tests showed moderate pancytopenia, hypercalcemia (serum calcium, 15.9 mg/dL), IgM lambda-type monoclonal gammopathy (IgG, 405 mg/dL; IgA, 42 mg/dL; and IgM, 2023 mg/dL), and lambda-type Bence-Jones protein in the urine (0.8 g/d).
Gene_expression (showed) of IgA in urine associated with pancytopenia and hypercalcemia
10) Confidence 0.65 Published 2003 Journal Eur. J. Haematol. Section Abstract Doc Link 12581194 Disease Relevance 1.59 Pain Relevance 0.10
CD79a was positive in all four cases studied; however, CD20 (L26) was positive in only two of four cases.
Gene_expression (positive) of CD79a
11) Confidence 0.65 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9669342 Disease Relevance 1.06 Pain Relevance 0.08
Detection of IgM- and IgA-anti VZV antibodies may be helpful in immunocompromised patients.
Gene_expression (Detection) of IgA associated with herpes zoster
12) Confidence 0.65 Published 2003 Journal J. Clin. Virol. Section Abstract Doc Link 12637076 Disease Relevance 1.50 Pain Relevance 0.33
Immunohistochemically, these lymphoid cells were positive for UCHL-1/CD45RO and CD3 and negative for CD79a, indicating that the tumor was a primary malignant T-cell lymphoma of the descending colon.
Neg (negative) Gene_expression (negative) of CD79a in descending colon associated with malignant neoplastic disease, lymphatic system cancer and cancer
13) Confidence 0.65 Published 2004 Journal J. Gastroenterol. Section Abstract Doc Link 15338374 Disease Relevance 1.05 Pain Relevance 0.08
The immediate AEs include headache, flushing, malaise, chest tightness, fever, chills, myalgia, fatigue, dyspnea, back pain, nausea, vomiting, diarrhea, blood pressure changes, tachycardia, and anaphylactic reactions, especially in IgA-deficient patients.
Gene_expression (deficient) of IgA in blood associated with heart rate under development, diarrhoea, vomiting, fever, increased venous pressure under development, myalgia, backache, anaphylaxis, cv unclassified under development, chills, headache, fatigue and dyspnea
14) Confidence 0.65 Published 2005 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 16391392 Disease Relevance 2.42 Pain Relevance 0.28
Very rare episodes of life-threatening anaphylaxis may occur, particularly in those IgA-deficient patients with anti-IgA antibodies; such patients should receive an IgA-depleted preparation of IVIG.
Gene_expression (deficient) of IgA associated with anaphylaxis
15) Confidence 0.65 Published 1993 Journal Drug Saf Section Abstract Doc Link 8260119 Disease Relevance 1.16 Pain Relevance 0.18
Five patients had positive antigliadin antibody (IgG for 2 patients and IgA for 3 patients).
Gene_expression (had) of IgA
16) Confidence 0.65 Published 2008 Journal Tunis Med Section Body Doc Link 19472779 Disease Relevance 0.22 Pain Relevance 0
Very rare episodes of life-threatening anaphylaxis may occur, particularly in those IgA-deficient patients with anti-IgA antibodies; such patients should receive an IgA-depleted preparation of IVIG.
Gene_expression (deficient) of IgA associated with anaphylaxis
17) Confidence 0.65 Published 1993 Journal Drug Saf Section Abstract Doc Link 8260119 Disease Relevance 1.21 Pain Relevance 0.18
Serum pepsinogen A (PgA) and pepsinogen C (PgC), the PgA:PgC ratio, and IgA and IgG antibodies to H. pylori were measured in all patients.
Gene_expression (measured) of IgA
18) Confidence 0.65 Published 1995 Journal Scand. J. Rheumatol. Section Abstract Doc Link 7481582 Disease Relevance 1.07 Pain Relevance 0.99
The laboratory data includes: IgG 1270 mg/dl, IgA 369mg/dl, IgM 326mg/dl, C'3 65.2 mg/dl, C'4 16.3 mg/dl, and serum soluble interleukin-2 receptor level (sIL-2R) greater than 6000U/ml.
Gene_expression (369mg/dl) of IgA
19) Confidence 0.65 Published 1992 Journal Zhonghua Yi Xue Za Zhi (Taipei) Section Abstract Doc Link 1316215 Disease Relevance 1.09 Pain Relevance 0.34
Both IgA-antibodies to Campylobacter and tissue-specific reactivity were often present in patients with short disease duration (< or = 1.5 years).
Gene_expression (present) of IgA associated with disease
20) Confidence 0.65 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15833374 Disease Relevance 0.73 Pain Relevance 0.17

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