INT212048

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 5.45
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPD) extracellular region (SFTPD) lysosome (SFTPD)
Anatomy Link Frequency
lung 1
SFTPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 18 100.00 Very High Very High Very High
rheumatoid arthritis 275 99.84 Very High Very High Very High
corticosteroid 3 96.56 Very High Very High Very High
Inflammation 163 89.36 High High
cytokine 11 88.32 High High
addiction 1 19.92 Low Low
methotrexate 45 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
visual analogue scale 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 170 100.00 Very High Very High Very High
Rheumatoid Arthritis 275 99.84 Very High Very High Very High
Pulmonary Disease 101 99.48 Very High Very High Very High
Disease 132 98.44 Very High Very High Very High
Congenital Anomalies 12 85.44 High High
Apoptosis 11 82.32 Quite High
Arthritis 25 80.44 Quite High
Obesity 133 77.20 Quite High
Nicotine Addiction 67 72.32 Quite High
Lung Injury 2 52.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we reported that the serum level of another collectin, surfactant protein D (SP-D), is decreased in newly-diagnosed, untreated RA [6].
Negative_regulation (decreased) of SP-D associated with rheumatoid arthritis
1) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.80 Pain Relevance 0.22
While confirming that SP-D in serum is significantly decreased in newly-diagnosed, untreated RA sufferers, we also found an inverse correlation between SP-D and measures of disease activity at baseline.
Negative_regulation (decreased) of SP-D associated with rheumatoid arthritis and disease
2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 1.10 Pain Relevance 0.34
Recently, we reported that the serum level of another collectin, surfactant protein D (SP-D), is decreased in newly-diagnosed, untreated RA [6].
Negative_regulation (decreased) of surfactant protein D associated with rheumatoid arthritis
3) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.81 Pain Relevance 0.22
Decreased SP-D in RA could be attributable to increased clearance from the circulation, for example, by deposition in inflamed tissues or complex formation with, for example, microbial or cellular waste [36,37].
Negative_regulation (Decreased) of SP-D associated with rheumatoid arthritis
4) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.96 Pain Relevance 0.29
The hydrophobic surfactant proteins SP-B and SP-C as well as SP-A, but not SP-D, were found to be significantly reduced (Table 2).
Negative_regulation (reduced) of SP-D
5) Confidence 0.19 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0 Pain Relevance 0
Recently, we reported that the serum level of another collectin, surfactant protein D (SP-D), is decreased in newly-diagnosed, untreated RA [6].
Negative_regulation (decreased) of collectin associated with rheumatoid arthritis
6) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.81 Pain Relevance 0.22
Also, reductions in serum levels of several inflammatory mediators including lung-specific proteins such as surfactant protein-D were observed in patients with moderate-tosevere COPD following therapy with inhaled corticosteroids [42, 43].

3.2.2.

Negative_regulation (reductions) of surfactant protein-D in lung associated with corticosteroid, inflammatory mediators and pulmonary disease
7) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 0.98 Pain Relevance 0.31

General Comments

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