INT212058

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 11.89
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Psmb10) cell morphogenesis (Psmb10) nucleus (Psmb10)
cytoplasm (Psmb10)
Anatomy Link Frequency
muscle 6
skeletal muscles 4
Psmb10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 40 96.00 Very High Very High Very High
Inflammation 20 95.60 Very High Very High Very High
tolerance 20 70.32 Quite High
adenocard 10 50.88 Quite High
Spinal cord 30 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Liver Neoplasms 60 99.50 Very High Very High Very High
Muscular Atrophy 100 99.34 Very High Very High Very High
Cancer 740 98.92 Very High Very High Very High
Stress 10 98.24 Very High Very High Very High
Frailty 220 97.48 Very High Very High Very High
Pressure And Volume Under Development 20 96.40 Very High Very High Very High
Appetite Loss 150 95.88 Very High Very High Very High
Hepatocellular Cancer 30 95.76 Very High Very High Very High
INFLAMMATION 20 95.60 Very High Very High Very High
Disease 10 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP-independent proteasome activity was increased in plantaris muscles from TB rats (p ?
Positive_regulation (increased) of proteasome in muscles
1) Confidence 0.01 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1950512 Disease Relevance 0.81 Pain Relevance 0
We have demonstrated that the decline in muscle mass in TB rats may be due, in part, to increased ATP-independent proteasome activity.
Positive_regulation (increased) of proteasome in muscle
2) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 1.24 Pain Relevance 0.09
We have demonstrated that the decline in muscle mass in TB rats may be due, in part, to increased ATP-independent proteasome activity.
Neg (independent) Positive_regulation (independent) of proteasome in muscle
3) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 1.24 Pain Relevance 0.09
Here, we showed that ATP-independent proteasome activities were stimulated in plantaris muscles from TB rats.
Positive_regulation (stimulated) of proteasome in muscles
4) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 1.49 Pain Relevance 0.10
Atrophied skeletal muscles from TB rats were also associated with increased ATP-independent proteasome activity.
Neg (independent) Positive_regulation (independent) of proteasome in skeletal muscles
5) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 0.54 Pain Relevance 0
In these studies, we hypothesized that skeletal muscles from rats bearing a tumor derived from Morris hepatoma MH7777 cells would have increased ATP-independent proteasome activity, which may contribute to systemic skeletal muscle atrophy.
Positive_regulation (increased) of proteasome in skeletal muscles associated with cancer, experimental liver neoplasms and muscular atrophy
6) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 1.49 Pain Relevance 0
Tumor-induced muscle atrophy appeared to be due, in part, to increased proteasome activity.
Positive_regulation (increased) of proteasome in muscle associated with cancer and muscular atrophy
7) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 2.01 Pain Relevance 0.08
Atrophied skeletal muscles from TB rats were also associated with increased ATP-independent proteasome activity.
Positive_regulation (increased) of proteasome in skeletal muscles
8) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 0.59 Pain Relevance 0
In contrast, atrophied plantaris muscles from TB rats had increased proteasome activity compared to Veh (0.12 ± 0.02 vs. 0.07 ± 0.01 AU/min/?
Positive_regulation (increased) of proteasome in muscles
9) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 0.36 Pain Relevance 0
Tumor-induced skeletal muscle protein loss appears to be due, in part, to increased activity of the ATP-ubiquitin-dependent proteasome system [9-11].
Positive_regulation (increased) of proteasome in skeletal muscle associated with cancer
10) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 2.11 Pain Relevance 0.05

General Comments

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