INT212083

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SSRP1) chromosome (SSRP1) plasma membrane (NOXO1)
nucleus (SSRP1) enzyme binding (NOXO1) DNA binding (SSRP1)
Anatomy Link Frequency
neurite 1
SSRP1 (Homo sapiens)
NOXO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 7 5.00 Very Low Very Low Very Low
induced neuropathy 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Peripheral nerve injury 1 5.00 Very Low Very Low Very Low
Chemotherapy induced neuropathy 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 32 99.28 Very High Very High Very High
Death 1 88.96 High High
Cancer 9 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Ovarian Cancer 2 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 2 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Leukemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether PXD could block Cisplatin induced neurite toxicity, three different concentrations of PXD were added to cells in combination with Cisplatin at the concentrations determined above to produce strong or moderate neurite toxicity.
Cisplatin Binding (combination) of PXD in neurite associated with toxicity
1) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.67 Pain Relevance 0

General Comments

This test has worked.

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