INT212084

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
plasma membrane (NOXO1) cell cycle (CDKN1A) enzyme binding (NOXO1)
Anatomy Link Frequency
neurite 1
NOXO1 (Homo sapiens)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 7 92.72 High High
Spinal cord 1 67.12 Quite High
Peripheral nerve injury 1 58.88 Quite High
induced neuropathy 3 17.60 Low Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Chemotherapy induced neuropathy 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 32 99.46 Very High Very High Very High
Cancer 9 99.40 Very High Very High Very High
Frailty 1 67.12 Quite High
Nervous System Injury 1 58.00 Quite High
Ovarian Cancer 2 39.84 Quite Low
Neuropathic Pain 9 39.12 Quite Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Leukemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the mechanism by which PXD blocked neurite toxicity is at this stage unknown, PXD has previously been shown to upregulate p21 Waf1/Cip1 in a range of cancer cell lines [19].
PXD Positive_regulation (upregulate) of Cip1 in neurite associated with toxicity and cancer
1) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.53 Pain Relevance 0.19

General Comments

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