INT212089

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NOXO1) enzyme binding (NOXO1)
NOXO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 21 91.44 High High
induced neuropathy 9 67.04 Quite High
diabetic neuropathy 4 21.36 Low Low
Potency 3 12.48 Low Low
peripheral neuropathy 8 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Peripheral nerve injury 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Chemotherapy induced neuropathy 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Nephropathy 3 94.32 High High
Toxicity 96 94.00 High High
Insulin Resistance 6 93.92 High High
Disease 3 87.52 High High
Diabetes Mellitus 53 81.44 Quite High
Metabolic Syndrome 4 79.72 Quite High
Neuropathic Pain 34 67.04 Quite High
Death 4 48.92 Quite Low
Cancer 27 45.16 Quite Low
Chronic Renal Failure 1 44.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is mainly dependent upon the activation of NADPH oxidase protein expression and activity (Wedgwood et al 2001; Li et al 2003; Romero et al 2008).
Gene_expression (expression) of NADPH oxidase protein
1) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 0.69 Pain Relevance 0
Cisplatin (Sigma) and PXD were provided by Novogen.
Gene_expression (provided) of PXD
2) Confidence 0.10 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.18 Pain Relevance 0.21
Consequently, although there appeared to be a slight protection by PXD, this was not significant by ANOVA, although comparison of Cisplatin 1 ?
Gene_expression (protection) of PXD
3) Confidence 0.08 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.71 Pain Relevance 0
When conducting the recovery experiments, the concentrations of PXD tested were decreased by 1 log to 10 nM, 100 nM and 1 ?
Gene_expression (concentrations) of PXD
4) Confidence 0.08 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.47 Pain Relevance 0

General Comments

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