INT212093

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.87
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP2) peptidase activity (CASP2) mitochondrion (CASP2)
aging (CASP2) nucleus (CASP2) intracellular (CASP2)
CASP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 579 100.00 Very High Very High Very High
alcohol 6 94.56 High High
Potency 2 86.68 High High
cocaine 3 80.48 Quite High
corticosteroid 3 79.52 Quite High
Chemotherapy induced neuropathy 1 75.08 Quite High
Nerve growth factor 7 52.64 Quite High
medulla 3 50.36 Quite High
Thalamus 3 48.68 Quite Low
induced neuropathy 3 45.68 Quite Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 312 100.00 Very High Very High Very High
Hematoma 105 100.00 Very High Very High Very High
Apoptosis 43 99.60 Very High Very High Very High
Nicotine Addiction 6 99.46 Very High Very High Very High
Cancer 128 98.44 Very High Very High Very High
Death 45 98.20 Very High Very High Very High
Hypertension 45 95.44 Very High Very High Very High
Cv General 3 Under Development 255 90.76 High High
Squamous Cell Carcinoma 5 90.60 High High
Hydrocephalus 21 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
III-tubulin),19 a condition that has been linked to failure of other microtubule-targeting agents such as taxanes and vinca alkaloids.20,21 As a class, epothilones also induce apoptosis through multiple pathways that appear to be distinct for this class of agents, including enhancement of caspase-2 activity and p53-mediated activation of the death effector Bax.15 In contrast, taxanes induce apoptosis mainly through caspase 9 activation.15
Positive_regulation (enhancement) of caspase-2 associated with apoptosis and death
1) Confidence 0.17 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004591 Disease Relevance 0.95 Pain Relevance 0
Time resolved analysis of the apoptotic processes showed a significant activation of caspase-2, -3, -6, and -9, and most importantly, rapid reduction of the mitochondrial membrane potential which clearly proved mitochondrial involvement in the apoptotic process.
Positive_regulation (activation) of caspase-2 associated with apoptosis
2) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.60 Pain Relevance 0
It induces apoptosis in a variety of cancer cell lines [15-17] by modulation of a number of apoptotic pathways including activation of caspase 2 and Bid signalling and inhibition of phosphorylation and degradation of the anti-apoptotic protein XIAP [17,18].
Positive_regulation (activation) of caspase 2 associated with cancer and apoptosis
3) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.75 Pain Relevance 0.17
Hematoma size is an important determinant of mortality after ICH and early hematoma growth, which is the increase in hematoma size within 6 hours after onset, is consistently associated with poor clinical outcomes [53,68-70] and an increased mortality rate [70].
Positive_regulation (increase) of ICH associated with hematoma and cva
4) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2646334 Disease Relevance 1.22 Pain Relevance 0.25
Anticoagulation with warfarin increases the risk of ICH by 5-to 10-fold in the general population [74], and approximately 15% of ICH cases overall are associated with its use.
Positive_regulation (increases) of ICH associated with cva
5) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2646334 Disease Relevance 0.74 Pain Relevance 0.25
Cigarette smoking has not been linked to an increased risk of ICH.
Positive_regulation (increased) of ICH associated with nicotine addiction and cva
6) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2646334 Disease Relevance 1.60 Pain Relevance 0.46

General Comments

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