INT212109

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.17
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
Anatomy Link Frequency
nucleus 1
RARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 53 95.84 Very High Very High Very High
opioid receptor 37 87.52 High High
neuropeptide release 1 80.28 Quite High
agonist 147 74.72 Quite High
Inflammation 34 73.20 Quite High
c fibre 7 66.88 Quite High
substance P 10 61.20 Quite High
antagonist 12 54.76 Quite High
Glutamate 1 39.60 Quite Low
Neurotransmitter 1 37.44 Quite Low
Disease Link Frequency Relevance Heat
Leukemia 18 100.00 Very High Very High Very High
Acute Promyelocytic Leukemia 1 97.40 Very High Very High Very High
Breast Cancer 39 96.88 Very High Very High Very High
Cough 93 96.84 Very High Very High Very High
Rheumatoid Arthritis 64 94.88 High High
Bronchitis 3 93.44 High High
Hypersensitivity 2 91.36 High High
Cancer 29 90.08 High High
Myeloid Leukemia 2 90.00 High High
Targeted Disruption 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sequences of the primers used were IL-6 (sense: 5'-CCGGAGAGGAGACTTCACAG-3', anti-sense: 5'-CCGGAGAGGAGACTTCACAG-3', NM 012589, 161 base pairs [bp], 59°C), RAR-?
Localization (sense) of RAR
1) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.04
For experiments of RAR subtype silencing, double-stranded small interfering RNA (siRNA) corresponding to a region of RAR-?
Localization (region) of RAR
2) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.07 Pain Relevance 0.03
Patients with these leukemias display translocations between the PML (promyelocytic leukemia) gene on chromosome 15 and the RARA (retinoic acid receptor ?)
Localization (translocations) of RARA associated with leukemia
3) Confidence 0.62 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 1.36 Pain Relevance 0
Co-amplification of RAR?
Localization (amplification) of RAR
4) Confidence 0.36 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.96 Pain Relevance 0
Therefore, under pathological conditions described above in the airway, changes in phenotype of the vagal nerves and tachykinin release from RAR fibers might facilitate glutamatergic transmission in the nucleus involved in cough reflex, leading to codeine-resistant cough.
Localization (release) of RAR in nucleus associated with cough and codeine
5) Confidence 0.06 Published 2007 Journal Cough Section Body Doc Link PMC1950526 Disease Relevance 0.77 Pain Relevance 0.73

General Comments

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