INT212124

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 6.72
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
choroid plexus 2
colon 1
neurons 1
CLC 1
ganglia 1
Cl (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 231 99.26 Very High Very High Very High
Hyperalgesia 60 98.02 Very High Very High Very High
Inflammation 102 97.76 Very High Very High Very High
Inflammatory stimuli 10 95.44 Very High Very High Very High
Bioavailability 2 93.68 High High
bradykinin 20 93.60 High High
Central nervous system 56 91.44 High High
imagery 37 87.52 High High
Potency 5 78.36 Quite High
addiction 15 77.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 223 99.88 Very High Very High Very High
Apoptosis 348 99.40 Very High Very High Very High
Adenocarcinoma 3 99.30 Very High Very High Very High
INFLAMMATION 346 99.06 Very High Very High Very High
Hyperalgesia 60 98.02 Very High Very High Very High
Targeted Disruption 72 97.72 Very High Very High Very High
Disease 71 95.60 Very High Very High Very High
Blindness 12 94.60 High High
Retina Disease 15 93.20 High High
Congenital Anomalies 15 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was the same on both sides of the membrane, so a pure Cl?
Gene_expression (same) of Cl
1) Confidence 0.11 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0 Pain Relevance 0
Furthermore, it is not clear that the Cl?
Neg (not) Spec (clear) Gene_expression (clear) of Cl
2) Confidence 0.11 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.25 Pain Relevance 0
Initially, F81C VRAC currents recorded with symmetrical Cl?
Gene_expression (recorded) of Cl
3) Confidence 0.11 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0 Pain Relevance 0
These questions, coupled with the observation that human bestrophin-1 (hBest1) can regulate voltage-gated Ca2+ channels (Rosenthal et al., 2005; Yu et al., 2008), has led to the suggestion that hBest1 is not a Cl?
Neg (not) Gene_expression (is) of Cl
4) Confidence 0.11 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.24 Pain Relevance 0
These questions, coupled with the observation that human bestrophin-1 (hBest1) can regulate voltage-gated Ca2+ channels (Rosenthal et al., 2005; Yu et al., 2008), has led to the suggestion that hBest1 is not a Cl?
Gene_expression (suggestion) of Cl
5) Confidence 0.11 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.24 Pain Relevance 0
To determine relative cation+/Cl?
Spec (determine) Gene_expression (determine) of Cl
6) Confidence 0.11 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0 Pain Relevance 0
Our results provide compelling evidence linking AE3 Cl?
Gene_expression (linking) of Cl
7) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.71 Pain Relevance 0
mice suggests additional roles played by the AE3 Cl?
Gene_expression (played) of Cl
8) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0
AE3 catalyzes electroneutral Cl?
Gene_expression (electroneutral) of Cl
9) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0.12
WRR-483 has recently completed pharmacokinetic and toxicology studies (SRI international) and was shown to possess a decent pharmacokinetic profile (Cl?
Gene_expression (profile) of Cl
10) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0.22 Pain Relevance 0.12
Treatment with tributyltin did not produce uniform Cl- levels even in the superficial cell layer of the ganglia.
Neg (not) Gene_expression (produce) of Cl in ganglia
11) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.12 Pain Relevance 0.06
Changes in expression of Cl- transporters correlate with Cl-accumulation
Gene_expression (expression) of Cl
12) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.48 Pain Relevance 0.24
Based on the hypothesis that modulation of the peripheral Cl- homeostasis is involved in the generation of inflammatory hyperalgesia, we examined the effects of inflammatory mediators on intracellular Cl- concentrations and on the expression levels of Cl- transporters in rat DRG neurons.


Gene_expression (expression) of Cl in neurons associated with inflammatory mediators, hyperalgesia and inflammation
13) Confidence 0.06 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2526990 Disease Relevance 0.68 Pain Relevance 0.39
We developed an in vitro assay for testing how inflammatory mediators influence Cl- concentration and the expression of Cl- transporters.
Gene_expression (expression) of Cl associated with inflammatory mediators
14) Confidence 0.06 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2526990 Disease Relevance 0.70 Pain Relevance 0.41
The CLC channel family, a group of voltage-dependent Cl?
Gene_expression (The) of Cl in CLC
15) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.54 Pain Relevance 0.04
Trigger and/or augmentation of outwardly rectifying Cl?
Gene_expression (rectifying) of Cl
16) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.64 Pain Relevance 0
After 3 hours of treatment, the efficiency of Cl- accumulation is further enhanced through upregulation of NKCC1 expression and reduced expression of the K+-Cl- co-transporter KCC2.
Gene_expression (expression) of Cl
17) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.68 Pain Relevance 0.52
We used a pair of equally lethal BALB/c colon adenocarcinomas, CT26 wild-type (CT26WT) and CT26.CL25 that expressed a tumor antigen, ?
Gene_expression (expressed) of CL25 in colon associated with adenocarcinoma and cancer
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001867 Disease Relevance 1.06 Pain Relevance 0
There are no functional data to support the expression of Ca2+-activated Cl- channels in the choroid plexus.
Gene_expression (expression) of Cl in choroid plexus
19) Confidence 0.01 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0.16 Pain Relevance 0
A possible explanation is that in the mammalian choroid plexus K+ efflux at the basolateral membrane is mediated via the K+-Cl- cotransporter (KCC3) which is expressed at this membrane in rat choroid plexus [76].
Gene_expression (expressed) of Cl in choroid plexus
20) Confidence 0.01 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.03

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