INT212125

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.88
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
Cl (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 138 100.00 Very High Very High Very High
Hyperalgesia 36 99.64 Very High Very High Very High
Inflammation 54 99.38 Very High Very High Very High
Inflammatory stimuli 6 94.52 High High
bradykinin 12 93.60 High High
imagery 17 87.52 High High
Root ganglion neuron 3 71.12 Quite High
allodynia 12 25.00 Low Low
gABA 45 5.00 Very Low Very Low Very Low
nociceptor 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 198 100.00 Very High Very High Very High
Hyperalgesia 36 99.64 Very High Very High Very High
Nociception 36 76.20 Quite High
Ganglion Cysts 8 75.00 Quite High
Blindness 4 50.00 Quite Low
Apoptosis 6 39.96 Quite Low
Congenital Anomalies 5 39.36 Quite Low
Death 6 36.24 Quite Low
Targeted Disruption 6 27.08 Quite Low
Neuropathic Pain 15 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mice suggests additional roles played by the AE3 Cl?
Regulation (roles) of Gene_expression (played) of Cl
1) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0
Changes in expression of Cl- transporters correlate with Cl-accumulation
Regulation (Changes) of Gene_expression (expression) of Cl
2) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.48 Pain Relevance 0.24
We developed an in vitro assay for testing how inflammatory mediators influence Cl- concentration and the expression of Cl- transporters.
Regulation (influence) of Gene_expression (expression) of Cl associated with inflammatory mediators
3) Confidence 0.03 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2526990 Disease Relevance 0.70 Pain Relevance 0.42
Based on the hypothesis that modulation of the peripheral Cl- homeostasis is involved in the generation of inflammatory hyperalgesia, we examined the effects of inflammatory mediators on intracellular Cl- concentrations and on the expression levels of Cl- transporters in rat DRG neurons.


Spec (examined) Regulation (effects) of Gene_expression (expression) of Cl in neurons associated with inflammatory mediators, hyperalgesia and inflammation
4) Confidence 0.03 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2526990 Disease Relevance 0.69 Pain Relevance 0.40

General Comments

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