INT212126

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 0.19
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc4a4) plasma membrane (Slc4a4)
Anatomy Link Frequency
astrocyte 1
Slc4a4 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 27 66.20 Quite High
imagery 14 25.92 Quite Low
Central nervous system 33 5.00 Very Low Very Low Very Low
potassium channel 18 5.00 Very Low Very Low Very Low
Action potential 18 5.00 Very Low Very Low Very Low
ketamine 14 5.00 Very Low Very Low Very Low
anesthesia 14 5.00 Very Low Very Low Very Low
Calcium channel 14 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Neuropathic pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 7 68.12 Quite High
Depression 27 66.20 Quite High
Blindness 28 50.00 Quite Low
Generalized Epilepsy 21 45.04 Quite Low
Ganglion Cysts 14 34.88 Quite Low
Apoptosis 42 31.76 Quite Low
Congenital Anomalies 35 31.16 Quite Low
Death 42 28.04 Quite Low
Pressure And Volume Under Development 30 24.04 Low Low
Targeted Disruption 51 18.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we examined the expression of CAII (whole lysate), and CAXIV and NBC1 (membrane) cellular fractions of freshly isolated Slc4a3?
Spec (examined) Gene_expression (expression) of NBC1
1) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.06 Pain Relevance 0.03
CAII, CAXIV, and NBC1 proteins were expressed by transient transfection of HEK293 cells[15], using the calcium phosphate method[16].
Gene_expression (expressed) of NBC1
2) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.07 Pain Relevance 0
NBC1 was also detectable in Slc4a3?
Gene_expression (detectable) of NBC1
3) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0
The AE3-mediated HCO3?
Gene_expression (The) of HCO3
4) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0
Tethering of CAXIV [39] and CAII [12] to AE3 maximizes the transmembrane HCO3?
Gene_expression (maximizes) of HCO3
5) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0
Both NBC1 [24] and carbonic anhydrase enzymes II (CAII) and XIV (CAXIV) [25], which are involved in bicarbonate metabolism and transport, are found in these same two cell types selectively expressing AE3.
Gene_expression (found) of NBC1
6) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.07 Pain Relevance 0.03
Notably, expression of CAII, CAXIV, and NBC1 increased by 30%, 35%, and 50%, respectively, in Slc4a3?
Gene_expression (ly, expres) of NBC1
7) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0
o during stimulation (compared to [9],[13] whereas mc3 and mc5 associated with H3 and H5 (NBC only and NBC+NKCC1, respectively) predict an increase in [Cl?]
Gene_expression (only) of NBC
8) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
o during stimulation (compared to [9],[13] whereas mc3 and mc5 associated with H3 and H5 (NBC only and NBC+NKCC1, respectively) predict an increase in [Cl?]
Gene_expression (respectively) of NBC
9) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
If we require that our models produce ion concentrations in the excited state that are consistent with empirically observed levels within the narrow time window relevant for the experimental ECS shrinkage observations, the presence of either NBC or NKCC1 or both seems necessary in order to produce ECS shrinkage to the extent reported in the literature.
Gene_expression (presence) of NBC
10) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
In the NBC case, the increase in [K+]o implies a depolarization of the astrocyte membrane which is sensed by the cotransporter to yield increased influx of both Na+ and HCO3?
Gene_expression (case) of NBC in astrocyte
11) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
o during stimulation (compared to [9],[13] whereas mc3 and mc5 associated with H3 and H5 (NBC only and NBC+NKCC1, respectively) predict an increase in [Cl?]
Gene_expression (only) of NBC
12) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
o during stimulation (compared to [9],[13] whereas mc3 and mc5 associated with H3 and H5 (NBC only and NBC+NKCC1, respectively) predict an increase in [Cl?]
Gene_expression (respectively) of NBC
13) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0

General Comments

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