INT212132

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.17
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc4a3) plasma membrane (Slc4a3)
Anatomy Link Frequency
photoreceptor 2
Slc4a3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 85.32 High High
Calcium channel 10 78.56 Quite High
Central nervous system 15 63.12 Quite High
depression 15 60.20 Quite High
ketamine 10 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 30 97.40 Very High Very High Very High
Targeted Disruption 15 85.36 High High
Night Blindness 5 85.00 Quite High
Ganglion Cysts 10 80.88 Quite High
Apoptosis 30 76.48 Quite High
Depression 15 60.20 Quite High
Blindness 20 50.00 Quite Low
Congenital Anomalies 25 5.00 Very Low Very Low Very Low
Retina Disease 15 5.00 Very Low Very Low Very Low
Generalized Epilepsy 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
regulatory proteins (CAII, CAXIV) suggests the occurrence of compensatory changes in response to the loss of AE3 in Slc4a3?
Negative_regulation (loss) of Slc4a3
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.30 Pain Relevance 0.04
The consequence of AE3 deficiency is a unique visual defect phenotype associated with a deregulation in pH mechanisms: a selective inner retina defect followed at later ages by photoreceptor degeneration.
Negative_regulation (deficiency) of AE3 in photoreceptor
2) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.18 Pain Relevance 0
We report that mice with homozygous disruption of Slc4a3 present with inner retinal defects and late onset photoreceptor death, which are the pathologic features of most human HVD [11].


Negative_regulation (disruption) of Slc4a3 in photoreceptor associated with death
3) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.18 Pain Relevance 0.09
regulatory proteins (CAII, CAXIV) suggests the occurrence of compensatory changes in response to the loss of AE3 in Slc4a3?
Negative_regulation (loss) of AE3
4) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.30 Pain Relevance 0.04
Furthermore, loss of AE3 in Müller cells likely affects their function, impacting on b-wave generation such as seen in Müller cell sheen dystrophy [30].
Negative_regulation (loss) of AE3
5) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.20 Pain Relevance 0.13

General Comments

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