INT212170

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.55
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CDIPT) endoplasmic reticulum (CDIPT) plasma membrane (CDIPT)
Anatomy Link Frequency
liver 1
CDIPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 2 74.96 Quite High
anticonvulsant 1 69.68 Quite High
tolerance 5 53.96 Quite High
Potency 5 52.48 Quite High
Central nervous system 3 12.28 Low Low
headache 7 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
drug abuse 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 11 97.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 422 94.72 High High
Congenital Anomalies 10 79.72 Quite High
Infection 76 71.88 Quite High
Myocardial Infarction 2 70.52 Quite High
Sprains And Strains 21 70.24 Quite High
Cardiovascular Disease 1 69.48 Quite High
Metabolic Syndrome 3 57.80 Quite High
Pressure And Volume Under Development 6 56.88 Quite High
Dyslipidemia /

Combined Dyslipidemia

5 55.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We retrieved the investigator and project demographics, including type of project administering institution (university, hospital, or other agency), department or work place affiliation of the PIs, funding award in Hong Kong dollars and project duration, from the fund's electronic management database.
Localization (affiliation) of PIs
1) Confidence 0.41 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC1952059 Disease Relevance 0 Pain Relevance 0
Like many other PIs, tipranavir is metabolized via the cytochrome (CYP) p450 3A4 isozyme.71 Tipranavir should always be coadministered with ritonavir because of its known inhibition of CYP 3A4 metabolism, resulting in a boosting effect.
Localization (metabolized) of PIs
2) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 0.12 Pain Relevance 0
Of note, I50L is only selected under ATV pressure and it causes higher susceptibility to other PIs such as amprenavir, darunavir, indinavir, lopinavir (LPV), nelfinavir (NFV) and saquinavir (SQV).6 The prevalence of I50L in large HIV drug resistance mutation databases is generally very low.7
Localization (causes) of PIs associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.10 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.30 Pain Relevance 0.03
In general, NNRTIs and PIs are metabolized in the liver and can induce or inhibit hepatic Cytochrome P450 enzymes such as CYP 3A4.
Localization (metabolized) of PIs in liver
4) Confidence 0.06 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 1.08 Pain Relevance 0.10

General Comments

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