INT212171

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.58
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CDIPT) endoplasmic reticulum (CDIPT) plasma membrane (CDIPT)
CDIPT (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 182 99.96 Very High Very High Very High
Potency 7 99.44 Very High Very High Very High
withdrawal 60 98.48 Very High Very High Very High
cocaine 16 97.82 Very High Very High Very High
Buprenorphine 116 96.88 Very High Very High Very High
opiate 14 79.48 Quite High
Opioid 64 77.40 Quite High
Oxycodone 6 66.32 Quite High
Pain 8 60.56 Quite High
Codeine 4 55.96 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 17 99.98 Very High Very High Very High
Congenital Anomalies 15 99.24 Very High Very High Very High
Lipodystrophy 5 98.96 Very High Very High Very High
Toxicity 45 97.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 163 95.04 Very High Very High Very High
Disease 9 94.72 High High
Substance Withdrawal Syndrome 30 94.52 High High
Urinary Calculi 1 84.76 Quite High
Urolithiasis 1 80.84 Quite High
Opiate Addiction 24 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Except for knowledge production, PIs were asked to estimate the contribution or expected impact of the research project on a categorical scale (considerable [?
Neg (Except) Gene_expression (asked) of PIs
1) Confidence 0.37 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC1952059 Disease Relevance 0 Pain Relevance 0
Together, darunavir’s rapid binding and slow disassociation confer a binding strength two orders of magnitude higher than any other protease inhibitor, which is believed to confer potency even against viral strains resistant to other PIs.4–6
Gene_expression (resistant) of PIs associated with sprains and strains and potency
2) Confidence 0.17 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724190 Disease Relevance 0.68 Pain Relevance 0.05
Mutation overlap with other PIs according to IAS is shown in Table 8, although mutations for older drugs such as indinavir, nelfinavir and saquinavir are likely under-represented due to lack of current research.29
Gene_expression (overlap) of PIs
3) Confidence 0.15 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724190 Disease Relevance 0.27 Pain Relevance 0
Following this observation a lack of involvement of the drug in morphological lipodystrophy abnormalities has been presumed, which is somewhat unique for PIs, although a longer follow-up is needed to confirm this singularity.50

Clinical experience

Gene_expression (unique) of PIs associated with congenital anomalies and lipodystrophy
4) Confidence 0.09 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.50 Pain Relevance 0.03
Several PIs that decrease methadone levels and cause methadone withdrawal have no clinically significant effects on buprenorphine levels, including lopinavir/ritonavir, nelfinavir [39•], and tipranavir/ritonavir [40••].
Gene_expression (decrease) of PIs associated with methadone, withdrawal and buprenorphine
5) Confidence 0.07 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2892618 Disease Relevance 0.71 Pain Relevance 2.16
If cocaine induces CYP3A4 in humans as well, it may decrease levels and effectiveness of the many ARVs that are CYP3A4 substrates, including most NNRTIs and PIs.
Gene_expression (substrates) of PIs associated with cocaine
6) Confidence 0.07 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2892618 Disease Relevance 0.42 Pain Relevance 0.68

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox