INT2122

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Context Info
Confidence 0.59
First Reported 1974
Last Reported 2010
Negated 4
Speculated 10
Reported most in Abstract
Documents 226
Total Number 236
Disease Relevance 26.92
Pain Relevance 92.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
pituitary 30
hypothalamus 28
median eminence 12
gonadal 12
POA 9
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 592 100.00 Very High Very High Very High
antagonist 386 100.00 Very High Very High Very High
Opioid 202 100.00 Very High Very High Very High
Dopamine 179 100.00 Very High Very High Very High
Endogenous opioid 141 100.00 Very High Very High Very High
opiate 127 100.00 Very High Very High Very High
cytokine 124 100.00 Very High Very High Very High
Enkephalin 118 100.00 Very High Very High Very High
Morphine 99 100.00 Very High Very High Very High
Immobilon 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 291 99.98 Very High Very High Very High
Urological Neuroanatomy 36 99.98 Very High Very High Very High
Hypoglycemia 22 99.98 Very High Very High Very High
Galactorrhea 65 99.90 Very High Very High Very High
Natriuresis 35 99.84 Very High Very High Very High
Uremia 24 99.84 Very High Very High Very High
Chronic Renal Failure 2 99.80 Very High Very High Very High
Cancer 107 99.64 Very High Very High Very High
Aging 14 99.62 Very High Very High Very High
Lordosis 37 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that M blocks the DA-mediated release of gonadotropin-releasing hormone in the rat hypothalamus.
Negative_regulation (blocks) of Localization (release) of gonadotropin-releasing hormone in hypothalamus associated with dopamine
1) Confidence 0.59 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 7043300 Disease Relevance 0.09 Pain Relevance 0.50
Evidence from our laboratory suggests that the hypothalamic impairment compromises regulation of the endogenous opioid system engendering a persistent opiatergic suppression of gonadotropin-releasing hormone secretion, which is subsequently reflected in a chronically low pituitary content of gonadotropin-releasing hormone receptors.
Negative_regulation (suppression) of Localization (secretion) of gonadotropin-releasing hormone in pituitary associated with endogenous opioid
2) Confidence 0.59 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2557144 Disease Relevance 0.17 Pain Relevance 0.10
PDBu-stimulated GnRH release was blocked by both tetrodotoxin and cocaine, known inhibitors of Na+ influx.
Negative_regulation (blocked) of Localization (release) of GnRH associated with tetrodotoxin and cocaine
3) Confidence 0.59 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.43
Because release of gonadotropin-releasing hormone into hypophysial portal blood can be observed under Althesin but is suppressed or blocked by chloralose-urethane, urethane, and pentobarbital, Althesin is the anesthetic of choice in studies concerned with the neural control of ovulatory hormone release.
Negative_regulation (blocked) of Localization (release) of gonadotropin-releasing hormone in neural
4) Confidence 0.59 Published 1984 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6744108 Disease Relevance 0 Pain Relevance 0.11
Because release of gonadotropin-releasing hormone into hypophysial portal blood can be observed under Althesin but is suppressed or blocked by chloralose-urethane, urethane, and pentobarbital, Althesin is the anesthetic of choice in studies concerned with the neural control of ovulatory hormone release.
Negative_regulation (suppressed) of Localization (release) of gonadotropin-releasing hormone in neural
5) Confidence 0.59 Published 1984 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6744108 Disease Relevance 0 Pain Relevance 0.11
The opiate agonist DAGO (10(-6)M) did not alter the basal release of LHRH; it, however, caused a significant decrease in the K+-induced release of LHRH from hypothalami derived from intact rats and rats replaced with physiological levels of testosterone but not from those derived from castrate rats or castrate rats replaced with small amounts of testosterone.
Negative_regulation (decrease) of Localization (release) of LHRH associated with agonist and opiate
6) Confidence 0.59 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3027600 Disease Relevance 0 Pain Relevance 0.60
NAL (1 mg/ml; 2.8 mM) increased basal GnRH release, but 0.01 mg NAL/ml suppressed basal GnRH release, and neither 0.001 nor 0.1 mg NAL/ml had an appreciable effect.
Negative_regulation (suppressed) of Localization (release) of GnRH associated with narcan
7) Confidence 0.59 Published 1988 Journal Endocrinology Section Abstract Doc Link 3058463 Disease Relevance 0 Pain Relevance 1.56
The ascorbate-induced release of LHRH was effectively blocked by the adrenergic alpha-receptor blocker phentolamine, but not by the beta-receptor blocker propranolol.
Negative_regulation (blocked) of Localization (release) of LHRH
8) Confidence 0.59 Published 1987 Journal Brain Res. Bull. Section Abstract Doc Link 2820553 Disease Relevance 0 Pain Relevance 0.26
In the presence of indomethacin or nordihydroguaiaretic acid, Diallyl-G is ineffective to further inhibit the release of GnRH.
Negative_regulation (inhibit) of Localization (release) of GnRH
9) Confidence 0.59 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8565043 Disease Relevance 0 Pain Relevance 0.93
The dose-dependent inhibitory effect of Diallyl-G on GnRH release is reversed by increasing concentrations of DTLET.
Negative_regulation (reversed) of Localization (release) of GnRH
10) Confidence 0.59 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8565043 Disease Relevance 0 Pain Relevance 0.79
Ouabain inhibited CuHis stimulation of LHRH release by 80%, whereas TTX and amiloride were ineffective.
Negative_regulation (inhibited) of Localization (release) of LHRH associated with tetrodotoxin
11) Confidence 0.59 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3027598 Disease Relevance 0 Pain Relevance 0.29
Using a static incubation system, adult male rats, either intact or castrate, with subtotal nephrectomy demonstrated a significant reduction of GnRH secretion by 25% in intact and by 40% in castrate uremic male rats compared with their nonuremic controls.
Negative_regulation (reduction) of Localization (secretion) of GnRH associated with uremia
12) Confidence 0.59 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1758577 Disease Relevance 0.79 Pain Relevance 0.29
In vitro, the potassium-induced release of GnRH from perifused medial hypothalami was reduced by 60% in 4-APP-treated male rats while hypothalamic GnRH content remained unchanged.
Negative_regulation (reduced) of Localization (release) of GnRH in medial
13) Confidence 0.59 Published 1985 Journal Endocrinology Section Abstract Doc Link 3886368 Disease Relevance 0.07 Pain Relevance 0.31
Rather, it is proposed that opioid inhibition of LHRH release and ovarian negative feedback may operate in parallel to control LH secretion in the female rat.
Negative_regulation (inhibition) of Localization (release) of LHRH associated with opioid
14) Confidence 0.59 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3135508 Disease Relevance 0 Pain Relevance 0.58
In the present study, we examined whether nicotine inhibits the pulsatile gonadotropin-releasing hormone (GnRH) release, and whether this inhibition of GnRH release by nicotine is mediated by the GABA receptor system, by checking in vitro pulsatile GnRH release from cultured GnRH neurons obtained from olfactory placodes of rat embryos at E13.5.
Spec (whether) Negative_regulation (inhibition) of Localization (release) of GnRH in embryos associated with gaba receptor and nicotine
15) Confidence 0.59 Published 2004 Journal Psychoneuroendocrinology Section Abstract Doc Link 15110924 Disease Relevance 0 Pain Relevance 0.45
Nicotine inhibition of pulsatile GnRH secretion is mediated by GABAA receptor system in the cultured rat embryonic olfactory placode.
Negative_regulation (inhibition) of Localization (secretion) of GnRH in olfactory placode associated with nicotine
16) Confidence 0.59 Published 2004 Journal Psychoneuroendocrinology Section Title Doc Link 15110924 Disease Relevance 0 Pain Relevance 0.53
It is therefore further argued that the inhibition of luteinizing hormone release alone is not sufficient to explain the dramatic decrease in lordosis behavior observed following exposure to an acute stressor.
Negative_regulation (inhibition) of Localization (release) of luteinizing hormone associated with lordosis
17) Confidence 0.58 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6685880 Disease Relevance 0.46 Pain Relevance 0.41
It is argued that the most likely mechanism by which endogenous opioids inhibit luteinizing hormone release and ovulation is by inhibiting luteinizing hormone releasing hormone release, and/or decreasing its production in the hypothalamus.
Negative_regulation (inhibit) of Localization (release) of luteinizing hormone in hypothalamus associated with endogenous opioid
18) Confidence 0.58 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6685880 Disease Relevance 0.46 Pain Relevance 0.46
Although the hypothalamic LHRH content does not necessarily reflect the release of LHRH, these results are in favour of the hypothesis that the release of hypothalamic LHRH is inhibited by the administration of morphine and is restored by the withdrawal of the narcotic.
Negative_regulation (inhibited) of Localization (release) of LHRH associated with withdrawal and morphine
19) Confidence 0.58 Published 1978 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 356791 Disease Relevance 0 Pain Relevance 0.67
These results support the hypothesis that melatonin has a suprapituitary site of action to inhibit LHRH release, and suggest that the site of its action may be located downstream to that of naloxone action and upstream to that of NMDA in the hypothalamic LHRH neuronal pathway.
Negative_regulation (inhibit) of Localization (release) of LHRH in neuronal associated with narcan
20) Confidence 0.58 Published 1999 Journal Endocr. J. Section Abstract Doc Link 10724360 Disease Relevance 0 Pain Relevance 0.44

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