INT21223

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.21
Pain Relevance 9.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
spinal 2
tail 2
brain 2
NS20Y 2
central canal 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 38 100.00 Very High Very High Very High
narcan 15 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
opioid receptor 17 99.80 Very High Very High Very High
Morphine 27 99.70 Very High Very High Very High
Buprenorphine 14 99.34 Very High Very High Very High
Kappa opioid receptor 9 99.32 Very High Very High Very High
tolerance 11 99.24 Very High Very High Very High
tail-flick 2 99.16 Very High Very High Very High
Analgesic 6 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 98.80 Very High Very High Very High
Appetite Loss 3 97.28 Very High Very High Very High
Targeted Disruption 9 94.56 High High
Nociception 5 92.80 High High
Pain 4 89.92 High High
Congenital Anomalies 1 87.44 High High
Hyperalgesia 2 83.44 Quite High
Pheochromocytoma 1 80.40 Quite High
Cognitive Disorder 1 75.00 Quite High
Drug Dependence 1 62.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increased expression of ORL1 receptors was also noted over the gray matter around the central canal.
Positive_regulation (increased) of Gene_expression (expression) of ORL1 in central canal
1) Confidence 0.70 Published 2005 Journal Indian J. Med. Res. Section Body Doc Link 15802762 Disease Relevance 0 Pain Relevance 0
Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence.
Positive_regulation (Enhanced) of Gene_expression (expression) of nociceptin receptor in spinal associated with addiction, orphanin, narcan, tolerance and morphine
2) Confidence 0.52 Published 2000 Journal J. Neurosci. Section Title Doc Link 11027224 Disease Relevance 0.28 Pain Relevance 1.75
An up-regulation of ORL1 expression was observed across all brain regions in delta-knockouts with cortical regions typically showing a 15-30% increase in binding that was most marked in heterozygous mice.
Positive_regulation (up-regulation) of Gene_expression (expression) of ORL1 in brain
3) Confidence 0.50 Published 2001 Journal Neuroscience Section Abstract Doc Link 11591451 Disease Relevance 0.23 Pain Relevance 0.30
Further, experiments on cultured cells transfected with nociceptin receptor cDNA show that NalBzoH competes [3H]-nociceptin binding and attenuates the nociceptin-induced inhibition of cAMP accumulation induced by forskolin.
Positive_regulation (transfected) of Gene_expression (transfected) of nociceptin receptor cDNA associated with orphanin
4) Confidence 0.50 Published 1999 Journal Brain Res. Section Abstract Doc Link 10612708 Disease Relevance 0.15 Pain Relevance 0.73
Experiments on the cultured cells transfected with the nociceptin receptor cDNA showed that NalBzoH competed with [3H]nociceptin binding and attenuated the nociceptin-induced inhibition of cAMP accumulation.
Positive_regulation (transfected) of Gene_expression (transfected) of nociceptin receptor cDNA associated with orphanin
5) Confidence 0.49 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9660760 Disease Relevance 0.81 Pain Relevance 1.15
In support of this hypothesis, the antinociceptive effect of buprenorphine, but not morphine, was markedly enhanced in mice lacking ORL-1 receptors using the tail-flick assay.
Positive_regulation (enhanced) of Neg (lacking) Gene_expression (lacking) of ORL-1 in tail associated with tail-flick, antinociceptive, morphine and buprenorphine
6) Confidence 0.48 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614092 Disease Relevance 0.07 Pain Relevance 2.63
These interactions between opiate agents can be explained assuming conformational transformation of the opiate receptor.
Positive_regulation (transformation) of Gene_expression (transformation) of opiate receptor associated with opiate
7) Confidence 0.48 Published 1980 Journal Prog Biochem Pharmacol Section Abstract Doc Link 6255489 Disease Relevance 0 Pain Relevance 1.08
Quantitative analysis showed an increased expression of ORL1 and mu receptors though the increase was not statistically significant.
Positive_regulation (increased) of Gene_expression (expression) of ORL1
8) Confidence 0.47 Published 2005 Journal Indian J. Med. Res. Section Body Doc Link 15802762 Disease Relevance 0 Pain Relevance 0
Recent studies have shown that cAMP analogs can induce expression of prepro (pp) orphanin FA (OFQ)/nociceptin-related gene products in NS20Y mouse neuroblastoma cells (Saito et al. [1996].
Positive_regulation (induce) of Gene_expression (expression) of nociceptin-related in NS20Y associated with neuroblastoma and orphanin
9) Confidence 0.45 Published 1999 Journal DNA Cell Biol. Section Abstract Doc Link 10025508 Disease Relevance 0.17 Pain Relevance 0.17
In Experiment 3, an increase in opiate receptor sensitivity produced by chronic naltrexone treatment did not affect the strength of the taste aversion, but resulted in an increase in the magnitude of the conditioned analgesic response.
Positive_regulation (increase) of Gene_expression (produced) of opiate receptor associated with appetite loss, analgesic and opiate
10) Confidence 0.44 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2167492 Disease Relevance 0.42 Pain Relevance 1.09
Following transfection of the kappa receptor cDNA into COS-1 cells, a receptor is expressed with the pharmacological specificity of a kappa opioid receptor.
Positive_regulation (transfection) of Gene_expression (transfection) of kappa receptor associated with kappa opioid receptor
11) Confidence 0.17 Published 1994 Journal Neuroscience Section Abstract Doc Link 7700508 Disease Relevance 0.08 Pain Relevance 0.33

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