INT212251

Context Info Confidence 0.14 First Reported 2007 Last Reported 2007 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0 Pain Relevance 0.41

Anatomy Mention Frequency body 1 A10L (Vaccinia virus) A10L - A10L (4) A10L - D14K (1)

Pain Term Frequency Confidence Heat conotoxin 132 97.68 Potency 24 90.08 antagonist 8 50.64 Analgesic 4 5.00 Neuropathic pain 4 5.00 Nicotine 24 5.00 addiction 4 5.00 gABA 4 5.00 agonist 16 5.00

Disease Term Frequency Confidence Heat Nicotine Addiction 4 5.00 Disease 8 5.00 Neuropathic Pain 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inde</span>ed, substitution of Arg5 in PnIA(A10L) produced a gain-of-function analog with similar properties to TxIA.

Gene_expression (produced) of A10L (A10L)

1) Confidence 0.14 Published 2007 Journal EMBO J Section Body Doc Link PMC1952216 Disease Relevance 0 Pain Relevance 0.17

The structure of TxIA(A10L) itself is very similar to other ?

Gene_expression (structure) of A10L (A10L)

2) Confidence 0.14 Published 2007 Journal EMBO J Section Body Doc Link PMC1952216 Disease Relevance 0 Pain Relevance 0.07

3° rigid body rotations of the monomers in the Ac-AChBP complex with PnIA(A10L D14K) (Celie et al, 2005a), whereas these rotations were not seen in the Ac-AChBP complex with ImI (Ulens et al, 2006).

Neg (not) Gene_expression (seen) of A10L D14K (A10L, D14K) in body

3) Confidence 0.13 Published 2007 Journal EMBO J Section Body Doc Link PMC1952216 Disease Relevance 0 Pain Relevance 0.08

The structure of Ac-AChBP in complex with TxIA(A10L) is very similar to other ?

Gene_expression (structure) of A10L (A10L)

4) Confidence 0.13 Published 2007 Journal EMBO J Section Body Doc Link PMC1952216 Disease Relevance 0 Pain Relevance 0.07

General Comments

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