INT212290

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.36
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2a, Grin2b) signal transduction (Grin2a) embryo development (Grin2b)
locomotion (Grin2a)
Anatomy Link Frequency
synapses 1
hippocampus 1
Grin2a (Rattus norvegicus)
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 99.96 Very High Very High Very High
nMDA receptor 19 98.64 Very High Very High Very High
depression 101 88.28 High High
long-term potentiation 73 88.00 High High
Spinal cord 2 87.84 High High
Glutamate receptor 27 81.68 Quite High
Dorsal horn 1 68.32 Quite High
Glutamate 17 60.84 Quite High
addiction 2 55.56 Quite High
Neurotransmitter 1 52.60 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 87 99.00 Very High Very High Very High
Depression 101 88.28 High High
Cognitive Disorder 1 84.16 Quite High
Obesity 1 82.36 Quite High
Ganglion Cysts 5 56.96 Quite High
Retinal Diseases 1 54.40 Quite High
Glaucoma 1 52.32 Quite High
Retina Disease 1 51.28 Quite High
Li-fraumeni Syndrome 2 49.56 Quite Low
Diabetic Retinopathy 9 35.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At this age, the composition of NMDA receptors on synapses is believed to undergo developmental changes, with the NR2B subunit in the receptor complex being replaced by NR2A subunit.
NR2A subunit Binding (replaced) of NR2B in synapses associated with nmda receptor
1) Confidence 0.20 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.38 Pain Relevance 0.43
In the hippocampus, immunoreactivity for NR2A and NR2B subunits are reduced in diabetic rats.
NR2A Binding (immunoreactivity) of NR2B in hippocampus associated with diabetes mellitus and hippocampus
2) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.98 Pain Relevance 0.40

General Comments

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