INT212293

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.10
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
arms 11
Vsnl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 16 100.00 Very High Very High Very High
imagery 2 97.16 Very High Very High Very High
Antihistamine 12 96.52 Very High Very High Very High
nMDA receptor 16 86.96 High High
depression 202 81.20 Quite High
Antiemetics 12 62.04 Quite High
long-term potentiation 146 54.88 Quite High
Anterior cingulate cortex 8 44.76 Quite Low
Pain 2 43.28 Quite Low
Dopamine 2 22.24 Low Low
Disease Link Frequency Relevance Heat
Infection 81 98.74 Very High Very High Very High
Sepsis 11 98.40 Very High Very High Very High
Vomiting 142 97.96 Very High Very High Very High
Adverse Drug Reaction 11 97.92 Very High Very High Very High
Eclampsia 11 93.88 High High
Birth Weight 6 93.00 High High
Ulcers 4 92.72 High High
Congenital Anomalies 4 92.32 High High
Sleep Disorders 4 91.28 High High
Hypertension 11 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was reported that the duration of NVP is reduced in older women as well as non-Hispanic black and Hispanic women, and is increased with higher gravidity; however, severity of NVP was not associated with any of the aforementioned risk factors.13
Gene_expression (duration) of NVP
1) Confidence 0.29 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990891 Disease Relevance 0.99 Pain Relevance 0.06
As the only drug approved for use in pregnancy, Diclectin® should be used as first-line therapy for the treatment of NVP symptoms in women, as studies have shown a 70% decrease in nausea and vomiting with its use.9

Antihistamines

Gene_expression (symptoms) of NVP associated with antihistamine and vomiting
2) Confidence 0.29 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990891 Disease Relevance 0.72 Pain Relevance 0.20
However, the response of NR2B-expressing cells to the same NVP concentration was also affected, being decreased by about 35–40% [29].
Gene_expression (expressing) of NVP
3) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.11 Pain Relevance 0.20
After recording such NMDA-EPSPs for 30–60 min, the NR2A antagonist NVP (0.4 ?
Gene_expression (antagonist) of NVP associated with antagonist
4) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.20 Pain Relevance 0.15
The most common abnormal laboratory tests were below normal haemoglobin and above normal aspartate aminotransferase (AST) levels; there were 24, 55, and 56 women in the NVP, NVP/CBV4, and NVP/CBV7 arms, respectively, whose AST levels were elevated above normal.
Gene_expression (arms) of NVP in arms
5) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.65 Pain Relevance 0
Following randomisation and delivery the most common adverse events were also infections: 4% (3/70), 6.7% (11/163), and 4.2% (7/168) for the NVP-only, NVP/CBV4, and NVP/CBV7 arms, respectively.
Gene_expression (arms) of NVP in arms associated with infection
6) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.91 Pain Relevance 0
An amended protocol was then used (see Text S1, S2, S3, S4, S5, S6, S7, S8 for protocol amendments); enrolment was continued into the NVP/CBV4 and NVP/CBV7 arms only, using the original randomisation schedule but rerandomising if the NVP arm appeared.
Gene_expression (arms) of NVP in arm
7) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.27 Pain Relevance 0
The most common abnormal laboratory tests were below normal haemoglobin and above normal aspartate aminotransferase (AST) levels; there were 24, 55, and 56 women in the NVP, NVP/CBV4, and NVP/CBV7 arms, respectively, whose AST levels were elevated above normal.
Gene_expression (arms) of NVP in arms
8) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.66 Pain Relevance 0
Following randomisation and delivery the most common adverse events were also infections: 4% (3/70), 6.7% (11/163), and 4.2% (7/168) for the NVP-only, NVP/CBV4, and NVP/CBV7 arms, respectively.
Gene_expression (arms) of NVP in arms associated with infection
9) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.91 Pain Relevance 0
To ensure that mislaid tablets did not result in poor adherence, mothers in the NVP/CBV4 and the NVP/CBV7 arms were dispensed 12 and 18 CBV tablets representing a total possible course of 6.5 and 9.5 d, respectively.
Gene_expression (arms) of NVP in arms
10) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.05 Pain Relevance 0
Postpartum sepsis was diagnosed in 1.3% (1/70), 3.1% (5/163), and 2.4% (4/168) for the NVP-only, NVP/CBV4, and NVP/CBV7 arms, respectively.
Gene_expression (arms) of NVP in arms associated with sepsis
11) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.83 Pain Relevance 0
An amended protocol was then used (see Text S1, S2, S3, S4, S5, S6, S7, S8 for protocol amendments); enrolment was continued into the NVP/CBV4 and NVP/CBV7 arms only, using the original randomisation schedule but rerandomising if the NVP arm appeared.
Gene_expression (arms) of NVP in arm
12) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.27 Pain Relevance 0
To ensure that mislaid tablets did not result in poor adherence, mothers in the NVP/CBV4 and the NVP/CBV7 arms were dispensed 12 and 18 CBV tablets representing a total possible course of 6.5 and 9.5 d, respectively.
Gene_expression (arms) of NVP in arms
13) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.05 Pain Relevance 0
The most common abnormal laboratory tests were below normal haemoglobin and above normal aspartate aminotransferase (AST) levels; there were 24, 55, and 56 women in the NVP, NVP/CBV4, and NVP/CBV7 arms, respectively, whose AST levels were elevated above normal.
Gene_expression (arms) of NVP in arms
14) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.66 Pain Relevance 0
Postpartum sepsis was diagnosed in 1.3% (1/70), 3.1% (5/163), and 2.4% (4/168) for the NVP-only, NVP/CBV4, and NVP/CBV7 arms, respectively.
Gene_expression (arms) of NVP in arms associated with sepsis
15) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.82 Pain Relevance 0

General Comments

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