INT2123

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 7
Speculated 8
Reported most in Abstract
Documents 209
Total Number 217
Disease Relevance 24.20
Pain Relevance 68.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
pituitary 24
plasma 10
neurons 10
hypothalamus 8
pituitary gland 8
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 501 100.00 Very High Very High Very High
narcan 427 100.00 Very High Very High Very High
substance P 239 100.00 Very High Very High Very High
gABA 219 100.00 Very High Very High Very High
cytokine 208 100.00 Very High Very High Very High
Morphine 121 100.00 Very High Very High Very High
opiate 101 100.00 Very High Very High Very High
Enkephalin 73 100.00 Very High Very High Very High
withdrawal 41 100.00 Very High Very High Very High
Catecholamine 22 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Uremia 9 100.00 Very High Very High Very High
Congenital Anomalies 6 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 202 99.62 Very High Very High Very High
Dysmenorrhea 15 99.36 Very High Very High Very High
Bordatella Infection 10 99.18 Very High Very High Very High
Thrombosis Related Under Development 6 99.04 Very High Very High Very High
Syndrome 17 98.98 Very High Very High Very High
Urological Neuroanatomy 97 98.88 Very High Very High Very High
Rheumatic Heart Disease 26 98.72 Very High Very High Very High
Eating Disorder 43 98.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lower dose of SP increased GnRH concentration later, only in the 2nd portal blood sample after intracarotid SP injection (p < 0.001).
Positive_regulation (increased) of GnRH in blood associated with substance p
1) Confidence 0.70 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9588691 Disease Relevance 0 Pain Relevance 0.56
Increase of gonadotropin-releasing hormone concentration in pituitary portal blood after substance P administration in male rats.
Positive_regulation (Increase) of gonadotropin-releasing hormone in pituitary associated with substance p
2) Confidence 0.70 Published 1998 Journal Neuroendocrinology Section Title Doc Link 9588691 Disease Relevance 0 Pain Relevance 0.36
Injection of SP into the internal carotid artery caused a significant increase in GnRH concentration in pituitary portal plasma only in INT rats.
Positive_regulation (increase) of GnRH in pituitary associated with substance p
3) Confidence 0.70 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9588691 Disease Relevance 0 Pain Relevance 0.47
Nicotine-induced increases in brain luteinizing hormone releasing hormone-like immunoreactivity and in serum luteinizing hormone levels of the male rat.
Positive_regulation (increases) of serum luteinizing hormone in brain associated with nicotine
4) Confidence 0.70 Published 1986 Journal Neurosci. Lett. Section Title Doc Link 3540734 Disease Relevance 0 Pain Relevance 0.30
Naloxone produces large increases in serum luteinizing hormone (LH) levels in normal males and females, supporting a role for endogenous opioids (EOP) in the tonic inhibition of LH.
Positive_regulation (increases) of serum luteinizing hormone associated with endogenous opioid and narcan
5) Confidence 0.70 Published 1985 Journal Life Sci. Section Abstract Doc Link 3894852 Disease Relevance 0 Pain Relevance 0.36
Furthermore results obtained following unilateral lesions indicate that a neural mechanism is involved in ovarian LHRH receptor induction and further reinforce our view that a direct neural connection links the brain and the ovaries.
Positive_regulation (induction) of LHRH receptor in neural
6) Confidence 0.70 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2995860 Disease Relevance 0.07 Pain Relevance 0
Lesions placed unilaterally (right or left) produced a significant increase of LHRH-R binding activity within the ovary ipsilateral to the lesion, while a reduction or no effect was observed in the contralateral gland.
Positive_regulation (increase) of LHRH-R in ovary
7) Confidence 0.70 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2995860 Disease Relevance 0.24 Pain Relevance 0.06
Proestrous rats treated with Althesin experienced a 5-fold increase in immuno-reactive luteinizing hormone releasing hormone (LHRH) concentration in methanolic extracts of pituitary stalk plasma.
Positive_regulation (increase) of LHRH in plasma
8) Confidence 0.69 Published 1982 Journal Endocr Res Commun Section Abstract Doc Link 7047147 Disease Relevance 0 Pain Relevance 0.07
Proestrous rats treated with Althesin experienced a 5-fold increase in immuno-reactive luteinizing hormone releasing hormone (LHRH) concentration in methanolic extracts of pituitary stalk plasma.
Positive_regulation (increase) of luteinizing hormone in plasma
9) Confidence 0.69 Published 1982 Journal Endocr Res Commun Section Abstract Doc Link 7047147 Disease Relevance 0 Pain Relevance 0.07
The Duncan's multiple range test indicated stalk plasma LHRH activity was significantly elevated in proestrous rats anesthetized with Althesin (p less than 0.05) but not with chloralose-urethane.
Positive_regulation (elevated) of LHRH in plasma
10) Confidence 0.69 Published 1982 Journal Endocr Res Commun Section Abstract Doc Link 7047147 Disease Relevance 0 Pain Relevance 0.07
In pituitary portal plasma collected from normal male rats, GnRH was significantly elevated by naloxone treatment, confirming that naloxone acted at the level of hypothalamic GnRH release.
Positive_regulation (elevated) of GnRH in plasma associated with narcan
11) Confidence 0.69 Published 1985 Journal Endocrinology Section Abstract Doc Link 3886368 Disease Relevance 0.07 Pain Relevance 0.34
The hypothalamic LHRH content of the nontolerant rats was increased 8 hr after the administration of morphine (100 mg/kg) when serum testosterone levels were depressed.
Positive_regulation (increased) of LHRH associated with morphine
12) Confidence 0.69 Published 1978 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 356791 Disease Relevance 0 Pain Relevance 0.65
Normally, LHRH message levels increase about the time of increased noradrenaline secretion just before the LH surge.
Positive_regulation (increase) of LHRH associated with noradrenaline
13) Confidence 0.69 Published 1992 Journal Ciba Found. Symp. Section Abstract Doc Link 1425026 Disease Relevance 0.09 Pain Relevance 0.82
These results suggest that norepinephrine facilitates LHRH pulse generator activity through both alpha- and beta-adrenergic-receptors, and that the action of opioid peptides on it requires an alpha-adrenergic receptor-mediated mechanism.
Positive_regulation (facilitates) of LHRH pulse generator associated with opioid
14) Confidence 0.69 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1758574 Disease Relevance 0 Pain Relevance 0.47
The onset of puberty implies changes from a prepubertal type of gonadotrophin secretion, characterized by a low activity of GnRH neurons, to an adult pattern of secretion with phasic and synchronous activation of GnRH neurons resulting in an increase in the amplitute and frequency of GnRH pulses.
Positive_regulation (activation) of GnRH in neurons
15) Confidence 0.69 Published 2001 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 11453030 Disease Relevance 0 Pain Relevance 0.31
The GnRH level of POA perfusate in OVX was increased by 146.6 +/- 46.5pg/ml (P < 0.01, n = 12) 30 minutes after intraperitoneal administration of naloxone, but no obvious change was found in INT following naloxone administration.
Positive_regulation (increased) of GnRH in POA associated with narcan
16) Confidence 0.69 Published 1994 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7750171 Disease Relevance 0 Pain Relevance 0.40
Given the variance of our analytical technique, we determined that there was a greater than 90% probability that we would have detected a 20% increase in GnRH mRNA had there been one.
Positive_regulation (increase) of GnRH
17) Confidence 0.69 Published 1989 Journal Endocrinology Section Abstract Doc Link 2647464 Disease Relevance 0.09 Pain Relevance 0.27
In addition, the NAL-induced LHRH response was higher from the MBH-POA of castrated H than that in castrated N rats.
Positive_regulation (induced) of LHRH in POA associated with narcan
18) Confidence 0.69 Published 1987 Journal Endocrinology Section Abstract Doc Link 3297642 Disease Relevance 0.15 Pain Relevance 0.41
Further, the first NAL infusion elicited a significant increase in LHRH output from the MBH-POA of N and H castrated rats, but it was significantly lower in comparison with that in their respective intact counterparts.
Positive_regulation (increase) of LHRH in POA associated with narcan
19) Confidence 0.69 Published 1987 Journal Endocrinology Section Abstract Doc Link 3297642 Disease Relevance 0.15 Pain Relevance 0.43
A significant increase in serum luteinizing hormone (LH) concentration was seen 15 min after naltrexone injection (20 mg/kg) at all ages studied; the increase was significantly higher (p less than 0.05) at 30 days of age than before or after that age.
Positive_regulation (increase) of serum luteinizing hormone
20) Confidence 0.69 Published 1989 Journal Biol. Reprod. Section Abstract Doc Link 2624852 Disease Relevance 0.09 Pain Relevance 0.22

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