INT212307

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2009
Negated 4
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.85
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
pronephros 4
MDCK 2
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 46 96.36 Very High Very High Very High
Kinase C 11 67.68 Quite High
long-term potentiation 1 65.40 Quite High
agonist 38 65.28 Quite High
antagonist 39 60.84 Quite High
depression 5 58.08 Quite High
qutenza 37 50.56 Quite High
nociceptor 46 50.00 Quite Low
Spinal cord 15 46.88 Quite Low
Substantia nigra 2 46.24 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 64 99.36 Very High Very High Very High
Stress 59 98.94 Very High Very High Very High
Cyst 15 98.80 Very High Very High Very High
Ganglion Cysts 48 96.36 Very High Very High Very High
Nociception 25 96.32 Very High Very High Very High
Polycystic Kidney Disease 35 88.32 High High
Cystic Kidney Diseases 5 81.76 Quite High
Pressure And Volume Under Development 50 68.12 Quite High
Anxiety Disorder 3 62.72 Quite High
Targeted Disruption 47 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, neither injection of trpv4MO (Fig. 4, C and E) nor coinjection of trpv4MO in combination with low concentrations of pkd2MO resulted in a significant increase in cyst formation in the zebrafish pronephros (Fig. 4, D and F).
Neg (nor) Regulation (resulted) of Gene_expression (coinjection) of trpv4MO in pronephros associated with cyst
1) Confidence 0.44 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.49 Pain Relevance 0
However, neither injection of trpv4MO (Fig. 4, C and E) nor coinjection of trpv4MO in combination with low concentrations of pkd2MO resulted in a significant increase in cyst formation in the zebrafish pronephros (Fig. 4, D and F).
Neg (nor) Regulation (resulted) of Gene_expression (injection) of trpv4MO in pronephros associated with cyst
2) Confidence 0.44 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.49 Pain Relevance 0
Co-expression of TRPV1 and TRPV4 ion channels, their modulation of synaptic transmission and their sensitization by PKC may synergistically play a role in nociception.


Regulation (modulation) of Gene_expression (expression) of TRPV4 associated with nociception
3) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.58 Pain Relevance 0.30
 ; Obara et al., 2006) targeting the splice donor of the third exon coding for part of the first transmembrane domain and part of the first extracellular loop, and trpv4MO (5?
Regulation (targeting) of Gene_expression (part) of trpv4MO
4) Confidence 0.39 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0 Pain Relevance 0
The presence of intracellular components that interact and regulate TRPV4 channel expression and function were evident from the fact that it cannot be activated by heat in a membrane de-limited condition [228], necessitating the presence of intracellular components as modulators.
Regulation (regulate) of Gene_expression (expression) of TRPV4
5) Confidence 0.38 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0 Pain Relevance 0.10
Genetically encoded loss-of-function of trpv4 results in a loss of shear stress-induced vasodilation, a response pattern critically dependent on endothelial TRPV4 expression.
Regulation (dependent) of Gene_expression (expression) of TRPV4 associated with stress and increased venous pressure under development
6) Confidence 0.27 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1959246 Disease Relevance 1.09 Pain Relevance 0
A modified target sequence II (TRPV4 IIm) with a two-base mismatch that does not affect TRPV4 expression was used as a negative control: 5?
Neg (not) Regulation (affect) of Gene_expression (expression) of TRPV4
7) Confidence 0.27 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0 Pain Relevance 0
Furthermore, robust flow-induced Ca2+ signals were observed in MDCK cells expressing a TRPV4 siRNA with a two-base mismatch, which does not alter TRPV4 expression levels (Fig.
Neg (not) Regulation (alter) of Gene_expression (expression) of TRPV4 in MDCK
8) Confidence 0.27 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.20 Pain Relevance 0

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