INT212362

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.85
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF3) extracellular region (CSF3) enzyme binding (CSF3)
Anatomy Link Frequency
granulocyte 4
bone marrow 2
CSF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 96.56 Very High Very High Very High
Inflammation 25 87.36 High High
adenocard 1 83.48 Quite High
depression 2 76.96 Quite High
corticosteroid 20 6.44 Low Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 39 100.00 Very High Very High Very High
Colorectal Cancer 95 99.84 Very High Very High Very High
Syndrome 215 99.82 Very High Very High Very High
Myelodysplastic Syndromes 5 98.22 Very High Very High Very High
Paraneoplastic Syndromes 5 96.80 Very High Very High Very High
Cancer 114 95.72 Very High Very High Very High
Metastasis 10 90.24 High High
INFLAMMATION 22 87.36 High High
Colon Cancer 15 85.96 High High
Necrosis 3 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum levels of both macrophage-colony stimulating factor (M-CSF) and granulocyte-colony stimulating factor are significantly higher in CRC patients than in healthy subjects [79,80].
Positive_regulation (higher) of Gene_expression (levels) of granulocyte-colony stimulating factor in granulocyte associated with colorectal cancer
1) Confidence 0.32 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.70 Pain Relevance 0
Another example supporting the role of cytokines in the pathogenesis of Sweet's syndrome is a patient with myelodysplastic syndrome-associated (non-granulocyte-colony stimulating factor-induced) Sweet's syndrome in whom elevated serum levels of granulocyte-colony stimulating factor and interleukin-6 were detected [128].
Positive_regulation (elevated) of Gene_expression (levels) of granulocyte-colony stimulating factor in granulocyte associated with syndrome, myelodysplastic syndromes and cytokine
2) Confidence 0.28 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1963326 Disease Relevance 1.58 Pain Relevance 0.07
In addition, another factor granulocyte colony stimulating factor produced by the malignant cells has also been attributed to be the cause of neutrophilia because of its action on bone marrow granulocytic cells [31-35].
Positive_regulation (attributed) of Gene_expression (produced) of granulocyte colony stimulating factor in bone marrow associated with malignant neoplastic disease
3) Confidence 0.18 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2819243 Disease Relevance 1.57 Pain Relevance 0.19

General Comments

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