INT212382

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.14
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (USF1) enzyme binding (USF1)
Anatomy Link Frequency
plasma 1
adipose tissue 1
USF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 8 91.80 High High
tolerance 3 83.80 Quite High
Pain 3 50.44 Quite High
Inflammation 3 35.60 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 381 100.00 Very High Very High Very High
Hyperlipidemia 49 100.00 Very High Very High Very High
Obesity 25 99.06 Very High Very High Very High
Cv General 3 Under Development 2 91.80 High High
Nicotine Addiction 2 88.48 High High
Disease 36 83.12 Quite High
Angina 6 82.88 Quite High
Disorder Of Lipid Metabolism 58 80.80 Quite High
Myocardial Infarction 3 78.60 Quite High
Coronary Artery Disease 20 77.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, the overlap between rs3737787 correlated genes and genes regulated by USF1 suggest that the effect of rs3737787 on FCHL is mediated through the transcription factor USF1.


Positive_regulation (mediated) of USF1 associated with familial combined hyperlipidemia
1) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.65 Pain Relevance 0
Our approach provides insight to how the SNP rs3737787 confers increased risk for FCHL, by demonstrating that it regulates the URFA module eigengene which in turn contributes to increased TG levels, a key component trait of FCHL.
Positive_regulation (increased) of FCHL associated with familial combined hyperlipidemia
2) Confidence 0.41 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.67 Pain Relevance 0
Our findings demonstrate that FADS3 expression is regulated by rs3737787 genotypes in adipose tissue, and that this differential expression causes increased risk for FCHL.
Positive_regulation (increased) of FCHL in adipose tissue associated with familial combined hyperlipidemia and obesity
3) Confidence 0.41 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.88 Pain Relevance 0
FCHL is caused by hepatic over-production of VLDL, either with or without impaired clearance of TG-rich lipoproteins from plasma.
Positive_regulation (caused) of FCHL in plasma associated with hyperlipidemia
4) Confidence 0.20 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1963453 Disease Relevance 0.93 Pain Relevance 0.27

General Comments

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