INT212383

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (VLDLR) transport (VLDLR) extracellular space (VLDLR)
plasma membrane (VLDLR) nucleus (VLDLR)
Anatomy Link Frequency
liver 1
neurons 1
intestine 1
VLDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 6 83.08 Quite High
Inflammation 18 77.52 Quite High
agonist 30 76.88 Quite High
abdominal pain 1 20.00 Low Low
Angina 12 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Somatosensory cortex 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 15 89.76 High High
Diabetes Mellitus 10 89.20 High High
Increased Venous Pressure Under Development 11 83.84 Quite High
Hyperlipidemia 34 82.44 Quite High
Metabolic Disorder 1 81.40 Quite High
INFLAMMATION 20 77.52 Quite High
Disorder Of Lipid Metabolism 38 64.72 Quite High
Coronary Artery Disease 63 59.92 Quite High
Myocardial Infarction 24 40.00 Quite Low
Cardiovascular Disease 7 36.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chylomicron is synthesized in the intestine, and very-low-density-lipoprotein (VLDL) is synthesized in the liver.
Gene_expression (synthesized) of very-low-density-lipoprotein in intestine
1) Confidence 0.28 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1963453 Disease Relevance 0.62 Pain Relevance 0
stimulates hepatic expression of the VLDL receptor (Vldlr) [24, 62].
Gene_expression (expression) of VLDL receptor
2) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.35 Pain Relevance 0.10
Reductions in the hepatic pool of cholesterol have been associated with a decrease in the rate of production of very-low-density lipoprotein (VLDL) by the liver (Thompson et al 1996).
Gene_expression (production) of very-low-density lipoprotein in liver
3) Confidence 0.14 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.22 Pain Relevance 0.04
ApoER2 and VLDLR exhibit overlapping but also distinct functions in the transduction of the reelin signaling [48].
Gene_expression (exhibit) of VLDLR
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
This is supported by Uchida et al. [57] who demonstrated that radially migrating neurons in the subventricular/intermediate zone strongly express functional VLDLR and ApoER2 receptors, which then downregulate in the cortical plate.
Gene_expression (express) of VLDLR in neurons
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0.04

General Comments

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