INT212403

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2007
Negated 3
Speculated 1
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 2.13
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
ventral 2
chiasm 1
dorsal 1
retina 1
Odz3 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 68 97.12 Very High Very High Very High
imagery 17 84.72 Quite High
Central nervous system 17 9.44 Low Low
tetrodotoxin 255 5.00 Very Low Very Low Very Low
sodium channel 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 816 99.68 Very High Very High Very High
Congenital Anomalies 34 99.40 Very High Very High Very High
Embryonic Lethality 17 96.04 Very High Very High Very High
Hypopigmentation 17 81.96 Quite High
Adhesions 68 67.68 Quite High
Ganglion Cysts 17 43.60 Quite Low
Vibrio Infection 17 22.08 Low Low
Sprains And Strains 17 5.00 Very Low Very Low Very Low
Overdose 17 5.00 Very Low Very Low Very Low
Strabismus 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative PCR showed that although Ten_m3 mRNA is present in the KO, it is significantly down-regulated (0.24 ± 0.05 fold; p < 0.001, Pairwise fixed reallocation randomisation test) compared to wild type (WT), suggesting that it may be targeted for degradation rather than synthesized into protein.
Gene_expression (present) of Ten_m3 mRNA associated with targeted disruption
1) Confidence 0.27 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.46 Pain Relevance 0
This was of particular interest both because Ten_m3 is expressed in geniculocortical neurons and in developing visual cortex [23], and because compensatory changes in geniculocortical projections have been reported in Siamese cats [19].
Gene_expression (expressed) of Ten_m3 in neurons
2) Confidence 0.27 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.06 Pain Relevance 0.05
As for the dLGN, this is likely to represent Ten_m3 expression in the vLGN neurons, as well as on retinal axons.


Gene_expression (expression) of Ten_m3 in neurons
3) Confidence 0.27 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.09 Pain Relevance 0
Ten_m3 expression was also observed, though at low levels, in the ventral LGN (vLGN; n.b.: the vLGN is a distinct nucleus of the ventral thalamus as opposed to the ventral region of the dLGN).
Gene_expression (expression) of Ten_m3 in ventral associated with thalamus
4) Confidence 0.24 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0 Pain Relevance 0.05
The above data demonstrate that the transmembrane protein Ten_m3 is expressed in both afferent axons and target structures of the developing visual pathway in a gradient that is consistently highest in regions that correspond topographically.
Gene_expression (expressed) of Ten_m3
5) Confidence 0.24 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.22 Pain Relevance 0
The expression pattern of Ten_m3, which extends beyond the VTC, is, however, not consistent with this possibility.
Gene_expression (expression) of Ten_m3
6) Confidence 0.24 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.09 Pain Relevance 0.04
In situ hybridisation showed that Ten_m3 was also expressed in the dorsal lateral geniculate nucleus (dLGN), where it was highest dorsally and lowest ventrally (Figure 1B).
Gene_expression (expressed) of Ten_m3 in dorsal lateral geniculate nucleus
7) Confidence 0.21 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0 Pain Relevance 0
Ten_m3 mRNA was expressed in the innermost layer of the developing retina, corresponding to the developing RGC layer at embryonic day (E)16 (Figure 1A).
Gene_expression (expressed) of Ten_m3 mRNA in retina
8) Confidence 0.21 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.06 Pain Relevance 0
Quantification along the long (dorsomedial to ventrolateral [DM-VL]) axis of the dLGN revealed that Ten_m3 expression is consistently in a linear gradient (Figure 1E).
Gene_expression (expression) of Ten_m3
9) Confidence 0.21 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0 Pain Relevance 0.03
Within the RGC layer, expression of mRNA for Ten_m3 was in a linear, high-ventral to low-dorsal gradient by P2 (Figure 1D).
Gene_expression (expression) of Ten_m3 in ventral
10) Confidence 0.21 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0 Pain Relevance 0
No ipsilateral terminals were observed following injections into dorsal retina, consistent with the retrograde tracing studies demonstrating that the absence of Ten_m3 results in a mapping, rather than a decussation, defect.
Neg (absence) Gene_expression (absence) of Ten_m3 in dorsal
11) Confidence 0.21 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.08 Pain Relevance 0.04
The observed alteration in the mapping of ipsilateral projections in Ten_m3 KOs could, therefore, potentially be accounted for by two distinct mechanisms: (1) axons from dorsal or nasal retina make an inappropriate choice at the optic chiasm and project ipsilaterally, but then make an appropriate topographic choice within the target itself (crossing defect, but in reverse direction to an albino); or (2) axons make an appropriate choice at the chiasm, but make an inappropriate topographic choice within the target nucleus (mapping defect).
Gene_expression (projections) of Ten_m3 in chiasm
12) Confidence 0.21 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.14 Pain Relevance 0
Mice that lack Ten_m3 show profound abnormalities in mapping of ipsilateral, but not contralateral, projections, and exhibit pronounced deficits when performing visually mediated behavioural tasks.
Neg (lack) Gene_expression (lack) of Ten_m3 associated with congenital anomalies
13) Confidence 0.21 Published 2007 Journal PLoS Biol Section Abstract Doc Link PMC1964777 Disease Relevance 0.10 Pain Relevance 0.04
Ten_m3 KOs often appeared a little smaller than their WT littermates during early postnatal development, although no specific developmental delays were evident.
Neg (little) Gene_expression (smaller) of Ten_m3
14) Confidence 0.21 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.56 Pain Relevance 0
We first analysed the normal expression of Ten_m3 in the developing visual pathway using in situ hybridisation.
Spec (analysed) Gene_expression (expression) of Ten_m3
15) Confidence 0.19 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.06 Pain Relevance 0
We recently identified Ten_m3 in a microarray screen for molecules that are differentially expressed between visual versus nonvisual pathways [23].
Gene_expression (expressed) of Ten_m3
16) Confidence 0.19 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.15 Pain Relevance 0
Expression of Ten_m3 in the Visual Pathway
Gene_expression (Expression) of Ten_m3
17) Confidence 0.19 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.06 Pain Relevance 0

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