INT212415

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.63
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKAB1) signal transduction (PRKAB1) nucleus (PRKAB1)
Anatomy Link Frequency
muscle cells 2
PRKAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 11 93.48 High High
alcohol 93 84.48 Quite High
addiction 3 76.52 Quite High
headache 5 62.12 Quite High
psoriasis 3 17.12 Low Low
endometriosis 3 16.52 Low Low
Glutamate 1 16.20 Low Low
Arthritis 2 15.92 Low Low
fibrosis 5 7.68 Low Low
Inflammation 29 7.16 Low Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 65 98.44 Very High Very High Very High
Apoptosis 43 98.36 Very High Very High Very High
Parkinson's Disease 2 97.76 Very High Very High Very High
Cv Unclassified Under Development 12 96.56 Very High Very High Very High
Cancer 275 96.20 Very High Very High Very High
Toxicity 13 93.16 High High
Disease 38 86.80 High High
Alcohol Addiction 24 85.04 High High
Restenosis 1 80.48 Quite High
Hyperglycemia 52 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have demonstrated that the R225W mutation increases basal and AMP-activated AMPK activities in differentiated muscle cells obtained from the vastus lateralis of carriers (Figure 3), and that ?
Positive_regulation (increases) of Positive_regulation (activated) of AMPK in muscle cells
1) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0 Pain Relevance 0
Our data further revealed that enhanced activation of Akt and AMPK, and subsequently, inhibition of Foxo3, apoptosis, and mitochondrial dysfunction may play a pivotal role in ALDH2 overexpression-induced cardioprotection against ethanol toxicity [130].
Positive_regulation (enhanced) of Positive_regulation (activation) of AMPK associated with parkinson's disease, toxicity and apoptosis
2) Confidence 0.20 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 1.18 Pain Relevance 0.27
Among all these agents, perhaps the most remarkable is metformin, which on targeting AMPK could be at least as – if not more – effective than mTOR, Fatty acid synthase, and mevalonate pathway inhibitors.
Positive_regulation (effective) of Positive_regulation (targeting) of AMPK
3) Confidence 0.16 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.70 Pain Relevance 0.09
Interestingly, these molecules also cause the stimulation of AMPK, indicating a common pathway intersection with metformin.
Positive_regulation (cause) of Positive_regulation (stimulation) of AMPK
4) Confidence 0.11 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 0.75 Pain Relevance 0

General Comments

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