INT212442

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) mitosis (HGF)
extracellular space (HGF) extracellular region (HGF) cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 3
HGF (Homo sapiens)
MET (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 3 73.92 Quite High
alcohol 6 31.52 Quite Low
Kinase C 4 5.00 Very Low Very Low Very Low
peptic ulcer disease 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 97.72 Very High Very High Very High
Liver Disease 12 92.72 High High
Infection 51 90.12 High High
Stress 1 80.12 Quite High
Fibrosis 9 73.92 Quite High
Hepatitis 33 68.16 Quite High
Body Weight 1 57.48 Quite High
Chronic Hepatitis 31 54.96 Quite High
Cancer 22 51.44 Quite High
Gastritis 10 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HGF activates the proto-oncogenic receptor tyrosine kinase c-MET and subsequent down-stream pathways, including the anti-apoptotic protein kinase-B (PKB/Akt) cascade, the proliferative MAP-kinase pathway (ERK1/2 and p38MAPK), and the STAT3 signaling (signal transducers and activators of transcription) [15-17].
HGF Positive_regulation (activates) of c-MET in HGF associated with apoptosis
1) Confidence 0.21 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 0.96 Pain Relevance 0.04
In order to construct a qualitative network model of c-Met activation by HGF and H. pylori we used here a methodology introduced previously [13,14] relying on logical interaction hypergraphs (LIH).
HGF Positive_regulation (activation) of c-Met in HGF
2) Confidence 0.00 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.23 Pain Relevance 0
Activation of the c-Met receptor by its endogenous ligand HGF leads to autophosphorylation of specific tyrosine residues in its cytoplasmic domain within the intracellular activation loop (Y1234 and Y1235) resulting in an activation of the intrinsic kinase activity.
HGF Positive_regulation (Activation) of c-Met in HGF
3) Confidence 0.00 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.06 Pain Relevance 0

General Comments

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