INT212457

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome segregation (Brca1) intracellular (Brca1) enzyme binding (Brca1)
DNA binding (Brca1) protein complex (Brca1) ligase activity (Brca1)
Brca1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 13.72 Low Low
fibrosis 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genomic Instability 2 89.68 High High
Targeted Disruption 6 84.32 Quite High
Breast Cancer 182 78.28 Quite High
Cancer 97 68.24 Quite High
Bladder Cancer 2 67.16 Quite High
Skin Cancer 1 66.40 Quite High
Lymphatic System Cancer 2 65.52 Quite High
Pancreatic Cancer 1 64.56 Quite High
Reprotox - General 1 1 63.80 Quite High
Male Breast Neoplasms 1 60.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BRCA1 and BRCA2 proteins are also found in complexes with Rad51, a protein important for the cellular response to DNA damage.192,194 In addition, BRCA1 is phosphorylated by the ATM/ATR kinases, in response to DNA damage (Fig. 1).
Phosphorylation (phosphorylated) of BRCA1
1) Confidence 0.51 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.91 Pain Relevance 0
ATM possesses kinase activity and phosphorylates serine and threonine amino acids in several important downstream cell cycle proteins such as p53, BRCA1/2, CHK1/2 and c-Abl [18,20,21].
Phosphorylation (phosphorylates) of BRCA1
2) Confidence 0.27 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.05 Pain Relevance 0

General Comments

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