INT212458

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.77
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
endothelial cells 1
neurons 1
hearts 1
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 12 67.24 Quite High
Osteoarthritis 2 44.48 Quite Low
anesthesia 9 41.92 Quite Low
fibrosis 33 14.48 Low Low
palliative 2 11.92 Low Low
cva 22 5.48 Low Low
Inflammation 33 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Limbic system 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 118 99.82 Very High Very High Very High
Targeted Disruption 31 99.20 Very High Very High Very High
Stress 11 99.12 Very High Very High Very High
Lifespan 20 98.80 Very High Very High Very High
Aging 37 96.92 Very High Very High Very High
Recurrence 68 96.80 Very High Very High Very High
Breast Cancer 178 96.64 Very High Very High Very High
Telangiectasia 51 95.44 Very High Very High Very High
Neurodegenerative Disease 20 94.64 High High
Disease 156 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, mTOR overactivation has been shown to cause increased mitochondrial biogenesis and accumulation of reactive oxygen species in distinct model systems[36], suggesting that the activation of mTOR pathway might be responsible for the detrimental effects of MEF2C activation and vice-versa to the beneficial effects of MEF2C depletion in the mechanically overloaded hearts.
mTOR Binding (overactivation) of in hearts
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.19 Pain Relevance 0
Compared to the unimpaired neurons in the control cases, in DLB brains, mTor and LC3 immunoreactivity were more abundant in neurons displaying ?
mTor Binding (immunoreactivity) of in neurons associated with parkinson's disease
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.71 Pain Relevance 0.03
This study supports the notion that defects in the autophagy pathway and more specifically in mTor and Atg7 are associated with neurodegeneration in DLB cases and ?
mTor Binding (associated) of associated with parkinson's disease
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 0.95 Pain Relevance 0
It is clear that understanding how exactly the IIS, GH and mTOR signalling pathways interact with one another to increase lifespan and healthspan is a key challenge to future research.
mTOR Spec (clear) Binding (interact) of associated with lifespan
4) Confidence 0.03 Published 2011 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC3001304 Disease Relevance 1.34 Pain Relevance 0
Sirolimus (rapamycin) impacts upon the mammalian target of rapamycin (mTOR) and causes a decrease in VEGF production and a reduction in the response of vascular endothelial cells to stimulation by VEGF (Dejneka et al. 2004).
mTOR Binding (target) of in endothelial cells
5) Confidence 0.02 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.48 Pain Relevance 0
Mammalian target of rapamycin (mTOR) regulates the translational response by phosphorylating components of the protein synthesis machinery.
mTOR Binding (target) of
6) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.76 Pain Relevance 0
FRAP FK506 binding protein 12-rapamycin associated protein (mTOR)
FRAP Binding (associated) of
7) Confidence 0.01 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 1.00 Pain Relevance 0
FRAP FK506 binding protein 12-rapamycin associated protein (mTOR)
mTOR Binding (associated) of
8) Confidence 0.01 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 1.00 Pain Relevance 0
The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding domain in the N-terminal of the protein necessary for activation of p53 in response to DNA damage, 3)the FAT domain – common for the PI3K-like family members FRAP, ATM and TRAPP, 4) a proline rich region shown to bind c-Abl and 5) an incomplete leucine zipper.
FRAP Binding (bind) of
9) Confidence 0.01 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.34 Pain Relevance 0

General Comments

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