INT212461

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Chek1) nucleus (Chek1) cell cycle (Chek1)
kinase activity (Chek1) cytoplasm (Chek1)
Chek1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 8.84 Low Low
fibrosis 7 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 7 55.92 Quite High
Breast Cancer 63 50.00 Quite Low
Cancer 7 45.88 Quite Low
Telangiectasia 17 38.00 Quite Low
Disease 6 35.36 Quite Low
Malignant Neoplastic Disease 4 29.84 Quite Low
Congenital Anomalies 2 9.72 Low Low
Recurrence 21 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 6 5.00 Very Low Very Low Very Low
Microcephaly 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATM possesses kinase activity and phosphorylates serine and threonine amino acids in several important downstream cell cycle proteins such as p53, BRCA1/2, CHK1/2 and c-Abl [18,20,21].
Gene_expression (/) of CHK1
1) Confidence 0.65 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0 Pain Relevance 0
More specifically, there was no significant reduction in the expression levels of Chk1, Brca1, Topbp1, Rad51, Ddb2, p73, Apaf1, or caspases which were all described to show reduced expression following MCPH1 knockdowns [34] (Tables S3, S4, S5).
Gene_expression (expression) of Chk1
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.11 Pain Relevance 0

General Comments

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