INT212466

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.72
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EPHB1) signal transduction (EPHB1) plasma membrane (EPHB1)
cytoplasm (EPHB1)
Anatomy Link Frequency
spinal cord 1
brain 1
stem cells 1
EPHB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 16 99.70 Very High Very High Very High
Spinal cord 2 99.40 Very High Very High Very High
Somatostatin 110 95.20 Very High Very High Very High
Dopamine 29 90.00 High High
biopsychosocial 8 89.32 High High
Neurotransmitter 22 86.08 High High
complementary and alternative medicine 22 85.76 High High
addiction 4 69.84 Quite High
Action potential 3 57.60 Quite High
agonist 5 45.40 Quite Low
Disease Link Frequency Relevance Heat
Neuroendocrine Cancer 71 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 122 99.36 Very High Very High Very High
Disease 80 99.12 Very High Very High Very High
Cancer 179 98.96 Very High Very High Very High
Insulinoma 12 97.68 Very High Very High Very High
Metastasis 44 93.80 High High
Mental Disorders 10 80.32 Quite High
Obesity 6 75.00 Quite High
Carcinoma 25 73.48 Quite High
Carcinoid 28 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A placebo controlled, double blind randomised clinical trial was designed to assess the effectiveness of NET on a cohort of children with medically diagnosed ADHD.
Regulation (effectiveness) of NET associated with attention deficit hyperactivity disorder
1) Confidence 0.37 Published 2009 Journal Trials Section Abstract Doc Link PMC2646715 Disease Relevance 0.63 Pain Relevance 0.19
A randomised controlled trial of the Neuro Emotional Technique (NET) for childhood Attention Deficit Hyperactivity Disorder (ADHD): a protocol

Background

Regulation (trial) of NET associated with attention deficit hyperactivity disorder
2) Confidence 0.37 Published 2009 Journal Trials Section Title Doc Link PMC2646715 Disease Relevance 0.66 Pain Relevance 0.20
Radiotherapy has been used successfully to control unresectable NET in the brain, spinal cord and bone [25].
Regulation (control) of NET in brain associated with neuroendocrine cancer and spinal cord
3) Confidence 0.11 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.54 Pain Relevance 0.05
Global gene expression analysis results showed that Oct4 regulated target genes which could be characterized as differentially regulated genes such as pluripotency markers NANOG, SOX2, and KLF4 and markers of undifferentiated stem cells FOXD1, CDC2, and EPHB1.
Regulation (regulated) of EPHB1 in stem cells
4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2747014 Disease Relevance 0.14 Pain Relevance 0.03
Imaging by SRS is not dependent on endocrine function of a NET but is determined by the tumour's endowment of SSTRs.
Neg (not) Regulation (dependent) of NET associated with cancer and imagery
5) Confidence 0.04 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.88 Pain Relevance 0.60
Radiotherapy has been used successfully to control unresectable NET in the brain, spinal cord and bone [25].
Regulation (control) of NET in spinal cord associated with neuroendocrine cancer and spinal cord
6) Confidence 0.04 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.54 Pain Relevance 0.05
Currently, we only know that DAT function is differentially regulated by different physiological and nonphysiological estrogens.58,148 Functional and structural homologies of the transporters suggest that similar estrogenic mechanisms could affect all transporters in this family (DAT, SERT, and NET).
Regulation (affect) of NET
7) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.15 Pain Relevance 0.15
Estrogens are already implicated in control of SERT and NET function and related disease etiologies.47,104 So while it is now well recognized that these transporters can be regulated by acute and selective responses via kinases and phosphatases, and that estrogens can activate kinases and phosphatases,140,151 it is unknown if estrogens will be one of the initial triggers of phosphoregulation of cellular neurotransmitter machineries, as has been shown for other targets.152,153

Xenoestrogens (nonphysiological estrogens) and their role in womenÂ’s mental health

Regulation (control) of NET associated with mental disorders, neurotransmitter and disease
8) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.18 Pain Relevance 0.15

General Comments

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